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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Plp1-Nfasc)2Brp
transgene insertion 2, Peter J Brophy
MGI:3808695
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Nfasctm1.1Brp/Nfasctm1.1Brp
Tg(Plp1-Nfasc)2Brp/0 		involves: 129P2/OlaHsd * C57BL/6 MGI:3808701


Genotype
MGI:3808701
cx1
Allelic
Composition		 Nfasctm1.1Brp/Nfasctm1.1Brp
Tg(Plp1-Nfasc)2Brp/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfasctm1.1Brp mutation (0 available); any Nfasc mutation (61 available)
Tg(Plp1-Nfasc)2Brp mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:139185 )
N
• axoglial junctions in the central and peripheral nervous system and sodium channel localization to nodes in the central nervous system are normal
abnormal axon morphology ( J:139185 )
• mice exhibit altered sodium channel localization within axons in the peripheral nervous system




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory