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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pofut1tm1Ysa
targeted mutation 1, Yumiko Saga
MGI:3808704
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Mesp1tm2(cre)Ysa/Mesp1+
Pofut1tm1Ysa/Pofut1tm1Ysa
Tg(CAG-cat,-Notch1)1Ysa/0 		involves: C3H * C57BL/6 * CBA * SJL MGI:3808715
cn2
 		Pofut1tm1Ysa/Pofut1tm1.1Ysa
Tg(Amh-cre)#Ysa/0 		involves: C3H/HeNJcl * C57BL/6NCrlj * C57BL/6NJcl * CBA/JNCrlj MGI:5426708
cn3
 		Nanos3tm2.1(cre)Ysa/Nanos3+
Pofut1tm1Ysa/Pofut1tm1.1Ysa 		involves: C3H/HeNJcl * C57BL/6NCrlj * C57BL/6NJcl * CBA/JNCrlj MGI:5426709
cn4
 		Mesp1tm2(cre)Ysa/Mesp1+
Pofut1tm1Ysa/Pofut1tm1Ysa 		involves: C57BL/6 * CBA * SJL MGI:3808714


Genotype
MGI:3808715
cn1
Allelic
Composition		 Mesp1tm2(cre)Ysa/Mesp1+
Pofut1tm1Ysa/Pofut1tm1Ysa
Tg(CAG-cat,-Notch1)1Ysa/0
Genetic
Background		 involves: C3H * C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mesp1tm2(cre)Ysa mutation (3 available); any Mesp1 mutation (18 available)
Pofut1tm1Ysa mutation (0 available); any Pofut1 mutation (22 available)
Tg(CAG-cat,-Notch1)1Ysa mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal heart development ( J:139209 )
• trabecular layer defects observed in Pofut1tm1Ysa/Pofut1tm1Ysa Mesp1tm2(cre)Ysa/Mesp1+ mice are partially rescued

growth/size/body
enlarged heart ( J:139209 )




Genotype
MGI:5426708
cn2
Allelic
Composition		 Pofut1tm1Ysa/Pofut1tm1.1Ysa
Tg(Amh-cre)#Ysa/0
Genetic
Background		 involves: C3H/HeNJcl * C57BL/6NCrlj * C57BL/6NJcl * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pofut1tm1.1Ysa mutation (0 available); any Pofut1 mutation (22 available)
Pofut1tm1Ysa mutation (0 available); any Pofut1 mutation (22 available)
Tg(Amh-cre)#Ysa mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality ( J:183324 )
• mice are not born at expected Mendelian frequency

reproductive system
reproductive system phenotype ( J:183324 )
N
• 8-week old mutant males produce normal litter sizes, have comparable testis size, as well as similar histology of the testis and epididymis to controls; similarly, 4-month old males generate normal litter size and have comparable testes histologically to control males




Genotype
MGI:5426709
cn3
Allelic
Composition		 Nanos3tm2.1(cre)Ysa/Nanos3+
Pofut1tm1Ysa/Pofut1tm1.1Ysa
Genetic
Background		 involves: C3H/HeNJcl * C57BL/6NCrlj * C57BL/6NJcl * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nanos3tm2.1(cre)Ysa mutation (1 available); any Nanos3 mutation (28 available)
Pofut1tm1.1Ysa mutation (0 available); any Pofut1 mutation (22 available)
Pofut1tm1Ysa mutation (0 available); any Pofut1 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:183324 )
N
• in 8-week old males, external morphology of the testes, histology of seminiferous tubules, and number of sperm in epididymides are normal; when bred to wild-type females, fecundity is similar to controls




Genotype
MGI:3808714
cn4
Allelic
Composition		 Mesp1tm2(cre)Ysa/Mesp1+
Pofut1tm1Ysa/Pofut1tm1Ysa
Genetic
Background		 involves: C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mesp1tm2(cre)Ysa mutation (3 available); any Mesp1 mutation (18 available)
Pofut1tm1Ysa mutation (0 available); any Pofut1 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis ( J:139209 )
• mice survive a little longer than knockout mice

cardiovascular system
myocardial trabeculae hypoplasia ( J:139209 )
• trabecular layers are underdeveloped
• endocardial layers are abnormally detached from myocardial layers
abnormal heart development ( J:139209 )
• valve formation is abnormal due to a lack of epithelial-mesenchymal transition and defective trabeculae

muscle
myocardial trabeculae hypoplasia ( J:139209 )
• trabecular layers are underdeveloped
• endocardial layers are abnormally detached from myocardial layers




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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory