mortality/aging
• mice die around E12.5
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embryo
• embryos are pale and fail to change from a U-shaped inverted blastoderm to a C-shaped body by E9.5
• embryos exhibit increased apoptosis at E12.5
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• at E10.5
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• at E10.5
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cellular
• embryonic cells cannot be used to establish embryonic fibroblast cell lines
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growth/size/body
• at E10.5
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• at E10.5
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nervous system