Phenotypes associated with this allele

• Allele Symbol: Itgb2^M1Btlr
• Allele Name: mutation 1, Bruce Beutler
• Allele ID: MGI:3808883
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Itgb2^M1Btlr/Itgb2^M1Btlr	C57BL/6J-Itgb2^M1Btlr	MGI:3808884

Genotype
MGI:3808884

hm1

• Allelic Composition: Itgb2^M1Btlr/Itgb2^M1Btlr
• Genetic Background: C57BL/6J-Itgb2^M1Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:139559 )

N • mice homozygous for this mutation are not susceptible to infection by mouse cytomegalovirus (MCMV)

abnormal NK cell differentiation ( J:139559 )

• NK cells of homozygous mutant mice arrest at the CD27⁺CD11b^- stage

• expression of KLRG-1 and CD43, two markers of the late stage in NK cell maturation, is reduced by half in homozygous mutant NK cells

• despite apparent defects in NK cell maturation, NK cell numbers are normal

• degranulation by mutant NK cells is normal

decreased interferon-gamma secretion ( J:139559 )

• homozygous mutant NK cells fail to produce interferon (IFN) gamma upon stimulation of Ly49D, an NK cell activating receptor

• however, IFN gamma production is normal in response to stimulation with YAC-1 or CHO-A7 cells, PMA/ionomycin, IL-12/IL-18, and antibodies to NK1.1

hematopoietic system

abnormal NK cell differentiation ( J:139559 )

• NK cells of homozygous mutant mice arrest at the CD27⁺CD11b^- stage

• expression of KLRG-1 and CD43, two markers of the late stage in NK cell maturation, is reduced by half in homozygous mutant NK cells

• despite apparent defects in NK cell maturation, NK cell numbers are normal

• degranulation by mutant NK cells is normal