Analysis Tools
nervous system
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• mutants show a lower AMPA to NMDA glutamate receptor ratio in hippocampal CA1 pyramidal neurons at 2 weeks of age, but not at 6-7 weeks of age
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• mutants show a lower AMPA to NMDA current ratio in hippocampal CA1 neurons at 2 weeks of age, but not at 6-7 weeks of age, indicating that glutamatergic neuerotransmission at synapses of hippocampal CA1 pyramidal neurons is altered during early postnatal development but not in adulthood
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• induction of NMDA receptor-dependent long-term potentiation following a low-frequency pairing protocol, but not theta-burst pairing protocol, is increased at 2 weeks of age but not in adulthood
• however, presynaptic paired-pulse potentiation in the hippocampal CA1 neurons and intrinsic postsynaptic excitability are unchanged in mutants and no differences in short- and long-term depression are seen
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• miniature currents are altered in mutants; AMPA mEPSCs are reduced in amplitude but not in frequency while NMDA mEPSCs are increased in amplitude
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| fragile X syndrome | DOID:14261 |
OMIM:300624 |
J:176553 | |
