Phenotypes associated with this allele

• Allele Symbol: Jdp2^tm1Kkyo
• Allele Name: targeted mutation 1, Kazunari K Yokoyama
• Allele ID: MGI:3808998
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Jdp2^tm1Kkyo/Jdp2^tm1Kkyo	involves: 129P2/OlaHsd * C57BL/6	MGI:4849503
hm2	Jdp2^tm1Kkyo/Jdp2^tm1Kkyo	involves: 129P2/OlaHsd * C57BL/6J	MGI:3809222

Genotype
MGI:4849503

hm1

• Allelic Composition: Jdp2^tm1Kkyo/Jdp2^tm1Kkyo
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell cycle ( J:166559 )

• mouse embryonic fibroblasts exhibit enhanced progression from G1- or G0-phase to S-phase and increased progression from a quiescent state to a proliferative state compared with wild-type cells

increased cell proliferation ( J:166559 )

• TPA-treated mice exhibit 1.3-fold increase in proliferating epidermal cells compared with similarly treated wild-type mice

• mouse embryonic fibroblasts exhibit increased cell proliferation compared with wild-type cells

homeostasis/metabolism

enhanced wound healing ( J:166559 )

• recovery from excision of full-thickness skin is faster than in similarly treated wild-type mice

limbs/digits/tail

short tail ( J:166559 )

• mice exhibit a short tail and reduced ratio of tail length to body length compared with wild-type mice

integument

thick skin ( J:166559 )

• TPA-treated mice exhibit a 1.4-fold increase in skin thickness compared with similarly treated wild-type mice

abnormal skin physiology ( J:166559 )

• TPA-treated mice exhibit a 1.4-fold increase in skin thickness and a 1.3-fold increase in proliferating epidermal cells compared with similarly treated wild-type mice

Genotype
MGI:3809222

hm2

• Allelic Composition: Jdp2^tm1Kkyo/Jdp2^tm1Kkyo
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

adipose tissue

abnormal fat cell morphology ( J:139241 )

• at 3 weeks of age, adipocytes contain larger lipid droplets than in wild-type adipocytes

• scapulae adipocytes preferentially differentiate into white adipose tissue compared to wild-type scapulae adipocytes that differentiate into brown adipose tissue

cellular

abnormal cell differentiation ( J:139241 )

• mouse embryonic fibroblasts (MEFs) exhibit increased ability to differentiate into adipose cells compared to wild-type MEFs