Analysis Tools
nervous system
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• tamoxifen treatment leads to the death of catecholaminergic neurons in the brain
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• 210 days after tamoxifen treatment, there is a substantial lose (about 50%) of tyrosine hydroxylase positive neurons in the substantia nigra adult mice
• there is also a drop in the total number of neurons in the substantia nigra after tamoxifen treatment
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• 210 days after tamoxifen treatment, there is a substantial lose (about 2.5-fold) of tyrosine hydroxylase positive neurons in the ventral tegmentum of adult mice
• there is also a drop in the total number of neurons in the ventral tegmentum after tamoxifen treatment
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• neurons are diminished in the locus ceruleus 210 days after tamoxifen treatment
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• fiber density of tyrosine hydroxylase positive neurons are diminished 210 days after tamoxifen treatment
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• fiber density of tyrosine hydroxylase positive neurons are diminished 210 days after tamoxifen treatment
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behavior/neurological
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• 100 days after tamoxifen injection, mice have reduced activity in open field tests with about 25% less activity
• resting time of mice in open field tests increases significantly 100 days after tamoxifen treatment
• this hypoactivity worsens with the passage of time
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cardiovascular system
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• tyrosine hydroxylase positive neurons are diminished by more than half 210 days after tamoxifen-treatment
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