Analysis Tools|
Allele Symbol Allele Name Allele ID |
Hcn4tm1(cre/ERT2)Anlu targeted mutation 1, Andreas Ludwig MGI:3809312 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• tamoxifen treated mice exhibit normal modulation of heart rate
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• tamoxifen treated mice are indistinguishable from wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• tamoxifen treated mice exhibit a more reduced heart rate in response to carbachol and adenosine A1-agonist CCPA compared to in similarly treated wild-type mice
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• following tamoxifen treatment, mice exhibit reduced hyperpolarization-activated current (If) density and faster activation kinetics of the residual current compared to in wild-type mice
• however, residual hyperpolarization-activated current (If) is normally blocked by cesium
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• following tamoxifen treatment, mice exhibit frequent sinus pauses in an otherwise normal electrocardiogram
• following tamoxifen treatment, 6 out of 11 sinoatrial nodes exhibit altered action potentials with membrane potentials that drift to hyperpolarization and cessation of discharge
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• approximately 20% of mice die suddenly with no ante-mortem indication of illness within 60 days after high dose tamoxifen treatment
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• ablation of sinoatrial node cells following tamoxifen treatment that varies depending on tamoxifen dose
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• tamoxifen induced ablation of sinoatrial node cells is accompanied by a destructive fibrosis of nodal tissue
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• following 5 days of tamoxifen treatment show alternating periods of slow and fast frequencies in R-R tachograms
• alterations of long electrical standstills (sinus pauses) and intermittent rapid atrial activity following tamoxifen treatment
• following 5 days of tamoxifen treatment absolute value of the maximally (isoprenaline) stimulated heart rate remained low
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• following 5 days of high or low dose tamoxifen treatment heart rate falls by about 40 - 50% or 12%, respectively
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• variety of cardiac rhythm disturbances; including sino-atrial arrhythmia, sino-atrial pause and to a minor extent supraventricular or ventricular tachycardia, following tamoxifen treatment
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• complete heart block some weeks after tamoxifen treatment
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• following tamoxifen treatment
• progressive prolongation of the P-R interval tends to result in complete isolated contraction of atria and ventricles with high dose tamoxifen treatment
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• ablation of sinoatrial node cells following tamoxifen treatment that varies depending on tamoxifen dose
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| sick sinus syndrome | DOID:13884 |
OMIM:163800 OMIM:608567 |
J:186021 | |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/05/2024 MGI 6.24 |
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