Phenotypes associated with this allele

• Allele Symbol: Sox2^tm1Okud
• Allele Name: targeted mutation 1, Akihiko Okuda
• Allele ID: MGI:3809487
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Sox2^tm1Okud/Sox2^tm1Okud Tg(Nes-cre)1Sasa/?	involves: 129P2/OlaHsd * C57BL/6	MGI:3809488

Genotype
MGI:3809488

cn1

• Allelic Composition: Sox2^tm1Okud/Sox2^tm1Okud; Tg(Nes-cre)1Sasa/?
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:138323 )

• mutant embryos were recovered at roughly the expected Mendelian ratio at all embryonic stages, but survived no longer than 12 hours post partum

nervous system

abnormal neuronal precursor proliferation ( J:138323 )

• decreased number of Ki67 antigen-positive cells and BrdU-labeled cells in the cortex and ganglionic eminence at E19.5

• the number of primary neurosphere colonies generated from brains of 14.5 dpc mutant embryos was reduced by about 50%

enlarged lateral ventricles ( J:138323 )

• mutant embryos at E19.5 exhibited moderately enlarged lateral ventricles

cellular

abnormal neuronal precursor proliferation ( J:138323 )

• decreased number of Ki67 antigen-positive cells and BrdU-labeled cells in the cortex and ganglionic eminence at E19.5

• the number of primary neurosphere colonies generated from brains of 14.5 dpc mutant embryos was reduced by about 50%