endocrine/exocrine glands
• fewer cells are induced to produce glucagons than in Pdx1tm1Macd/Pdx1+ Tg(tetO-Neurog3)8Ggu mice
|
Allele Symbol Allele Name Allele ID |
Tg(tetO-Myt1)2Ggu transgene insertion 2, Guoqiang Gu MGI:3809520 |
||||||||||||
Summary |
2 genotypes
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• fewer cells are induced to produce glucagons than in Pdx1tm1Macd/Pdx1+ Tg(tetO-Neurog3)8Ggu mice
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mice exhibit precocious endocrine differentiation, converting 1.8-fold more pancreatic cells to glucagon producing, immature alpha cells at E11.5 than in Pdx1tm1Macd heterozygotes
• however, this conversion is not sustained later in development as E18.5, only rare glucagons producing cells are found
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 09/03/2024 MGI 6.24 |
![]() |
|