All Phenotypes Tg(tetO-Myt1)2Ggu MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(tetO-Myt1)2Ggu
transgene insertion 2, Guoqiang Gu
MGI:3809520

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Neurog3^{tm1.1(cre/ERT)Ggu}/Neurog3⁺ Pdx1^tm1Macd/Pdx1⁺ Tg(tetO-Myt1)2Ggu/0	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ	MGI:3809541
cx2	Pdx1^tm1Macd/Pdx1⁺ Tg(tetO-Myt1)2Ggu/0	involves: 129S1/Sv * 129X1/SvJ	MGI:3809543

Allelic Composition	Neurog3^{tm1.1(cre/ERT)Ggu}/Neurog3⁺ Pdx1^tm1Macd/Pdx1⁺ Tg(tetO-Myt1)2Ggu/0
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Neurog3^{tm1.1(cre/ERT)Ggu} mutation (0 available); any Neurog3 mutation (19 available)
Pdx1^tm1Macd mutation (1 available); any Pdx1 mutation (35 available)
Tg(tetO-Myt1)2Ggu mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal pancreatic islet morphology ( J:136131 )

• fewer cells are induced to produce glucagons than in Pdx1^tm1Macd/Pdx1⁺ Tg(tetO-Neurog3)8Ggu mice

Allelic Composition	Pdx1^tm1Macd/Pdx1⁺ Tg(tetO-Myt1)2Ggu/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdx1^tm1Macd mutation (1 available); any Pdx1 mutation (35 available)
Tg(tetO-Myt1)2Ggu mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal pancreas development ( J:136131 )

• however, this conversion is not sustained later in development as E18.5, only rare glucagons producing cells are found

• mice exhibit precocious endocrine differentiation, converting 1.8-fold more pancreatic cells to glucagon producing, immature alpha cells at E11.5 than in Pdx1^tm1Macd heterozygotes

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