Phenotypes associated with this allele

• Allele Symbol: Gt(ROSA)26Sor^{tm6(CAG-ZsGreen1)Hze}
• Allele Name: targeted mutation 6, Hongkui Zeng
• Allele ID: MGI:3809522
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Gt(ROSA)26Sor^tm6(CAG-ZsGreen1)Hze/Gt(ROSA)26Sor^+	involves: 129S6/SvEvTac * C57BL/6NCr	MGI:4436850
cn2	Chd7^tm1.1Dmm/Chd7^tm1.1Dmm Gt(ROSA)26Sor^tm6(CAG-ZsGreen1)Hze/Gt(ROSA)26Sor^+ Tg(Atoh1-cre)1Bfri/0	involves: 129 * C57BL/6 * C57BL/6NCrl * CBA	MGI:7518647
cn3	Chd7^tm1.1Dmm/Chd7^tm1.1Dmm Gt(ROSA)26Sor^tm6(CAG-ZsGreen1)Hze/Gt(ROSA)26Sor^+ Shh^tm1(EGFP/cre)Cjt/Shh^+	involves: 129S1/SvlmJ * 129S6/SvEvTac * C57BL/6J * SJL/J	MGI:7518701
cn4	Chd7^Gt(S20-7E1)Sor/Chd7^tm1.1Dmm Gt(ROSA)26Sor^tm6(CAG-ZsGreen1)Hze/Gt(ROSA)26Sor^+ Tg(Neurog1-cre)1Jejo/0	involves: 129S * C57BL/6 * SJL/J	MGI:7518675

Genotype
MGI:4436850

ht1

• Allelic Composition: Gt(ROSA)26Sor^{tm6(CAG-ZsGreen1)Hze}/Gt(ROSA)26Sor⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:155793 )

• mice are viable and fertile; used for cre reporter expression analysis

Genotype
MGI:7518647

cn2

• Allelic Composition: Chd7^tm1.1Dmm/Chd7^tm1.1Dmm; Gt(ROSA)26Sor^{tm6(CAG-ZsGreen1)Hze}/Gt(ROSA)26Sor⁺; Tg(Atoh1-cre)1Bfri/0
• Genetic Background: involves: 129 * C57BL/6 * C57BL/6NCrl * CBA

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:310063 )

N • hair cells are preserved in the apical, mid, and basal cochlear regions

Genotype
MGI:7518701

cn3

• Allelic Composition: Chd7^tm1.1Dmm/Chd7^tm1.1Dmm; Gt(ROSA)26Sor^{tm6(CAG-ZsGreen1)Hze}/Gt(ROSA)26Sor⁺; Shh^{tm1(EGFP/cre)Cjt}/Shh⁺
• Genetic Background: involves: 129S1/SvlmJ * 129S6/SvEvTac * C57BL/6J * SJL/J

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:310063 )

N • normal hair cells and neurites at P1 in the cochlea

Genotype
MGI:7518675

cn4

• Allelic Composition: Chd7^{Gt(S20-7E1)Sor}/Chd7^tm1.1Dmm; Gt(ROSA)26Sor^{tm6(CAG-ZsGreen1)Hze}/Gt(ROSA)26Sor⁺; Tg(Neurog1-cre)1Jejo/0
• Genetic Background: involves: 129S * C57BL/6 * SJL/J

nervous system

abnormal vestibulocochlear ganglion morphology ( J:310063 )

• in the apical region of the cochlea aberrant axonal projections that cross, loop, and extend beyond the epithelium are seen

• at P1 total area of the spiral ganglion is reduced