Phenotypes associated with this allele

• Allele Symbol: Gapt^tm1.1Wz
• Allele Name: targeted mutation 1.1, Weiguo Zhang
• Allele ID: MGI:3809581
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gapt^tm1.1Wz/Gapt^tm1.1Wz	Not Specified	MGI:3809586

Genotype
MGI:3809586

hm1

• Allelic Composition: Gapt^tm1.1Wz/Gapt^tm1.1Wz
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:138146 )

N • B and T cell development, humoral response and BCR-mediated signaling are normal

increased B cell proliferation ( J:138146 )

• following stimulation with anti-CD40 antibodies, LPS or anti-IgM antibodies, mice exhibit increased B cell proliferation compared to in wild-type cells that is most significant at low levels of anti-IgM concentrations

increased marginal zone B cell number ( J:138146 )

• in old mice

increased IgG2b level ( J:138146 )

increased IgG3 level ( J:138146 )

increased IgM level ( J:138146 )

hematopoietic system

increased B cell proliferation ( J:138146 )

• following stimulation with anti-CD40 antibodies, LPS or anti-IgM antibodies, mice exhibit increased B cell proliferation compared to in wild-type cells that is most significant at low levels of anti-IgM concentrations

increased marginal zone B cell number ( J:138146 )

• in old mice

increased IgG2b level ( J:138146 )

increased IgG3 level ( J:138146 )

increased IgM level ( J:138146 )

cellular

increased B cell proliferation ( J:138146 )

• following stimulation with anti-CD40 antibodies, LPS or anti-IgM antibodies, mice exhibit increased B cell proliferation compared to in wild-type cells that is most significant at low levels of anti-IgM concentrations