Phenotypes associated with this allele

• Allele Symbol: Rigi^tm1Zgwg
• Allele Name: targeted mutation 1, Zhugang Wang
• Allele ID: MGI:3809597
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rigi^tm1Zgwg/Rigi^tm1Zgwg	involves: 129S1/Sv	MGI:3810515

Genotype
MGI:3810515

hm1

• Allelic Composition: Rigi^tm1Zgwg/Rigi^tm1Zgwg
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:139016 )

N • despite displaying granulocytosis, mice exhibit normal numbers of common myeloid precursors, granulocytic and monocytic precursors, and megakaryocytic and erythroid precursors

colitis ( J:139868 )

• at 8 weeks, mice develop colitis

increased susceptibility to induced colitis ( J:139868 )

• following treatment with DSS, mice exhibit more severe damage and inflammatory infiltration of the mucosa of the colon, increased weight loss and higher fecal scores compared to similarly treated wild-type mice

enlarged spleen ( J:139016 )

• at 9 months

abnormal B cell differentiation ( J:139016 )

• B cell production is hampered in the bone marrow and spleen

abnormal granulocyte morphology ( J:139016 )

• mice exhibit granulocytes with enlarged cellular and nuclear sizes unlike in wild-type mice

increased granulocyte number ( J:139016 )

• beginning 6 weeks after birth and progressing with age

increased memory T cell number ( J:139868 )

• mice exhibit an increase in the percentages of CD44^highCD62L^high memory T cells in the CD4+ splenic compartments compared to in wild-type mice

decreased T cell number ( J:139868 )

• mice exhibit a decreased in the number of CD44^lowCD62L^high naive T cells in the CD4+ and CD8+ compartments of the spleen compared to in wild-type mice

increased activated T cell number ( J:139868 )

• mice exhibit an increase in the percentages of CD44^highCD62L^low effector T cells in the CD4+ and CD8+ splenic compartments compared to in wild-type mice

abnormal granulocyte physiology ( J:139016 )

• cell autonomous granulocyte proliferation and survivability is increased leading to the development of chronic myelocytic leukemia

decreased Peyer's patch number ( J:139868 )

• mice exhibit reduced Peyer's patch numbers associated with increased apoptosis in the Peyer's patches compared to wild-type mice

small Peyer's patches ( J:139868 )

• mice exhibit reduced Peyer's patch size associated with increased apoptosis in the Peyer's patches compared to wild-type mice

neoplasm

increased chronic myelocytic leukemia incidence ( J:139016 )

• chronic myelocytic leukemia develops at 9 months with enlarged spleens infiltrated with granulocytes

• by 16 months, 90% of mice exhibit chronic myelocytic leukemia

• granulocyte proliferation and survivability is increased leading to the development of chronic myelocytic leukemia

growth/size/body

weight loss ( J:139868 )

• from 3 months of age

enlarged spleen ( J:139016 )

• at 9 months

digestive/alimentary system

colitis ( J:139868 )

• at 8 weeks, mice develop colitis

increased susceptibility to induced colitis ( J:139868 )

• following treatment with DSS, mice exhibit more severe damage and inflammatory infiltration of the mucosa of the colon, increased weight loss and higher fecal scores compared to similarly treated wild-type mice

hematopoietic system

enlarged spleen ( J:139016 )

• at 9 months

abnormal B cell differentiation ( J:139016 )

• B cell production is hampered in the bone marrow and spleen

extramedullary hematopoiesis ( J:139016 )

• decreased erythroid production in the bone marrow is compensated for by increased erythropoiesis in the spleen

abnormal granulocyte morphology ( J:139016 )

• mice exhibit granulocytes with enlarged cellular and nuclear sizes unlike in wild-type mice

increased granulocyte number ( J:139016 )

• beginning 6 weeks after birth and progressing with age

increased memory T cell number ( J:139868 )

• mice exhibit an increase in the percentages of CD44^highCD62L^high memory T cells in the CD4+ splenic compartments compared to in wild-type mice

decreased T cell number ( J:139868 )

• mice exhibit a decreased in the number of CD44^lowCD62L^high naive T cells in the CD4+ and CD8+ compartments of the spleen compared to in wild-type mice

increased activated T cell number ( J:139868 )

• mice exhibit an increase in the percentages of CD44^highCD62L^low effector T cells in the CD4+ and CD8+ splenic compartments compared to in wild-type mice

abnormal granulocyte physiology ( J:139016 )

• cell autonomous granulocyte proliferation and survivability is increased leading to the development of chronic myelocytic leukemia