All Phenotypes Myd88<tm1Defr> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Myd88^tm1Defr/Myd88^tm1Defr Tg(Itgax-cre)1-1Reiz/0	B6.Cg-Myd88^tm1Defr Tg(Itgax-cre)1-1Reiz	MGI:3809643
cn2	Myd88^tm1Defr/Myd88^tm1Defr Tnip1^tm1.2Ama/Tnip1^tm1.2Ama Tg(Itgax-cre)1-1Reiz/0	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA	MGI:5547520
cn3	Lyn^tm1.1Calo/Lyn^tm1.1Calo Myd88^tm1Defr/Myd88^tm1Defr Tg(Itgax-cre)1-1Reiz/0	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:5545814
cn4	Myd88^tm1Defr/Myd88^tm1Defr Tg(Vil1-cre)997Gum/0	involves: 129P2/OlaHsd * C57BL/6J * SJL	MGI:5297575
cn5	Myd88^tm1Defr/Myd88^tm1Defr Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:3809645

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal dendritic cell differentiation ( J:139001 )

• dendritic cell maturation mediated by injections of TLR9 agonists is diminished in these mice

• maturation markers on DCs such as I-A^b, CD80, and CD86 have several fold lower expression than in controls

abnormal T-helper 1 cell differentiation ( J:139001 )

• less Th1 T cells develop when nave antigen-specific T cells are transferred into these mice with cognate antigen and a TLR9 agonist

decreased IgG1 level ( J:139001 )

• antigen specific IgG1 levels are lower by almost an order of magnitude compared to controls after immunization with OVA-peptide and TLR9 agonist

decreased IgG2b level ( J:139001 )

• antigen specific IgG2b levels are lower by an order of magnitude compared to controls after immunization with OVA-peptide and TLR9 agonist

decreased IgG2c level ( J:139001 )

• antigen specific IgG2c levels are lower by several orders of magnitude than controls after immunization with OVA-peptide and TLR9 agonist

abnormal NK cell physiology ( J:139001 )

• NK cells in vivo make much several fold less IFN-gamma in response to injections of TLR9 agonists

• there is also a reduction in IFN-gamma production upon LPS administration

decreased circulating interleukin-12b level ( J:139001 )

• mice fail to make IL-12p40 in response to the TLR9 agonist CpG-containing oligodeoxynucleotide ODN1826

• IL-12p40 production is reduced 5- to 30- fold in response to agonists to TLR1 +TLR2, TLR4, TLR5, TLR7, or TLR9

decreased circulating interleukin-6 level ( J:139001 )

• circulating levels of IL-6 one hour after TLR9 stimulation is half that in wild-type controls

abnormal dendritic cell physiology ( J:139001 )

• DCs fail to secrete cytokines in response to TLR9 agonists

abnormal dendritic cell antigen presentation ( J:139001 )

• nave antigen-specific T cells expand at a much slower rate when transferred into these mice with cognate antigen and TLR9 agonist

homeostasis/metabolism

decreased circulating interleukin-12b level ( J:139001 )

• mice fail to make IL-12p40 in response to the TLR9 agonist CpG-containing oligodeoxynucleotide ODN1826

• IL-12p40 production is reduced 5- to 30- fold in response to agonists to TLR1 +TLR2, TLR4, TLR5, TLR7, or TLR9

decreased circulating interleukin-6 level ( J:139001 )

• circulating levels of IL-6 one hour after TLR9 stimulation is half that in wild-type controls

hematopoietic system

abnormal dendritic cell differentiation ( J:139001 )

• dendritic cell maturation mediated by injections of TLR9 agonists is diminished in these mice

• maturation markers on DCs such as I-A^b, CD80, and CD86 have several fold lower expression than in controls

abnormal T-helper 1 cell differentiation ( J:139001 )

• less Th1 T cells develop when nave antigen-specific T cells are transferred into these mice with cognate antigen and a TLR9 agonist

decreased IgG1 level ( J:139001 )

• antigen specific IgG1 levels are lower by almost an order of magnitude compared to controls after immunization with OVA-peptide and TLR9 agonist

decreased IgG2b level ( J:139001 )

• antigen specific IgG2b levels are lower by an order of magnitude compared to controls after immunization with OVA-peptide and TLR9 agonist

decreased IgG2c level ( J:139001 )

• antigen specific IgG2c levels are lower by several orders of magnitude than controls after immunization with OVA-peptide and TLR9 agonist

abnormal NK cell physiology ( J:139001 )

• NK cells in vivo make much several fold less IFN-gamma in response to injections of TLR9 agonists

• there is also a reduction in IFN-gamma production upon LPS administration

cellular

abnormal dendritic cell differentiation ( J:139001 )

• dendritic cell maturation mediated by injections of TLR9 agonists is diminished in these mice

• maturation markers on DCs such as I-A^b, CD80, and CD86 have several fold lower expression than in controls

Allelic Composition	Myd88^tm1Defr/Myd88^tm1Defr Tnip1^tm1.2Ama/Tnip1^tm1.2Ama Tg(Itgax-cre)1-1Reiz/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myd88^tm1Defr mutation (4 available); any Myd88 mutation (52 available)
Tg(Itgax-cre)1-1Reiz mutation (4 available)
Tnip1^tm1.2Ama mutation (0 available); any Tnip1 mutation (57 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:205446 )

N	• unlike Tnip1^tm1.1Ama/Tnip1^tm1.1Ama Tg(Itgax-cre)1-1Reiz hematopoietic stem cells used in transplantation experiments, hematopoietic stem cells do not alter susceptibility to IMQ-induced psoriasis

immune system

immune system phenotype ( J:205446 )

N	• unlike Tnip1^tm1.1Ama/Tnip1^tm1.1Ama Tg(Itgax-cre)1-1Reiz mice, mice exhibit normal spleen mass, myeloid cell numbers and activated T lymphocyte

Allelic Composition	Lyn^tm1.1Calo/Lyn^tm1.1Calo Myd88^tm1Defr/Myd88^tm1Defr Tg(Itgax-cre)1-1Reiz/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyn^tm1.1Calo mutation (0 available); any Lyn mutation (65 available)
Myd88^tm1Defr mutation (4 available); any Myd88 mutation (52 available)
Tg(Itgax-cre)1-1Reiz mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:200745 )

N	• inflammation seen in mutant mice wild-type for Myd88 is reversed and mice do not develop autoantibodies

renal/urinary system

renal/urinary system phenotype ( J:200745 )

N	• kidneys are of normal size and cellularity and show no signs of inflammation

Allelic Composition	Myd88^tm1Defr/Myd88^tm1Defr Tg(Vil1-cre)997Gum/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myd88^tm1Defr mutation (4 available); any Myd88 mutation (52 available)
Tg(Vil1-cre)997Gum mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

abnormal gut flora balance ( J:177506 )

• mice exhibit a higher mucosal bacterial loads compared with Myd88^tm1Defr control mice but not as much as in Myd88 null or conditionally knocked-out mice

• however, luminal bacterial loads are normal

Allelic Composition	Myd88^tm1Defr/Myd88^tm1Defr Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10^{Tg(Vav1-icre)A2Kio} mutation (3 available); any Commd10 mutation (24 available)
Myd88^tm1Defr mutation (4 available); any Myd88 mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal NK cell physiology ( J:139001 )

• NK cells fail to make IFN-gamma in response to injections of TLR9 agonists

• NK cells in vivo have a blunted IFN-gamma response to LPS injections

hematopoietic system

abnormal NK cell physiology ( J:139001 )

• NK cells fail to make IFN-gamma in response to injections of TLR9 agonists

• NK cells in vivo have a blunted IFN-gamma response to LPS injections

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