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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sgo2aGt(D025B05)Wrst
gene trap D025B05, Wolfgang Wurst
MGI:3809644
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sgo2aGt(D025B05)Wrst/Sgo2aGt(D025B05)Wrst involves: 129S2/SvPas * C57BL/6 MGI:3809646


Genotype
MGI:3809646
hm1
Allelic
Composition		 Sgo2aGt(D025B05)Wrst/Sgo2aGt(D025B05)Wrst
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sgo2aGt(D025B05)Wrst mutation (0 available); any Sgo2a mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
small testis ( J:138779 )
• about 35% smaller than controls
oligozoospermia ( J:138779 )
• about a 40% reduction in the number of sperm
abnormal spermatid morphology ( J:138779 )
• decrease in the number of mature spermatids
abnormal female meiosis ( J:138779 )
• C-banded metaphase II chromosomes show 40 individual chromatids compared to 20 chromosomes in wild-type controls
arrest of male meiosis ( J:138779 )
• a very high percentage of cells are arrested at metaphase II
• during meiosis II sister chromatids are not held together at the centromeres and fail to congress to a typical metaphase II plate
• loss of sister kinetochore cohesion during the metaphase/anaphase I transition
• however, axial/lateral elements and synaptonemal complex formation are normal

behavior/neurological
behavior/neurological phenotype ( J:138779 )
N
• no evidence of sexual behavior dysfunction is detected

cellular
cellular phenotype ( J:138779 )
N
• no significant differences are seen in proliferation rate, mitotic index, stress induced proliferative arrest, incidence of chromatid cohesion defects, or spindle assembly checkpoint function in mutant MEFs compared to wild-type MEFs
oligozoospermia ( J:138779 )
• about a 40% reduction in the number of sperm
abnormal spermatid morphology ( J:138779 )
• decrease in the number of mature spermatids
abnormal female meiosis ( J:138779 )
• C-banded metaphase II chromosomes show 40 individual chromatids compared to 20 chromosomes in wild-type controls
arrest of male meiosis ( J:138779 )
• however, axial/lateral elements and synaptonemal complex formation are normal
• a very high percentage of cells are arrested at metaphase II
• during meiosis II sister chromatids are not held together at the centromeres and fail to congress to a typical metaphase II plate
• loss of sister kinetochore cohesion during the metaphase/anaphase I transition

endocrine/exocrine glands
small testis ( J:138779 )
• about 35% smaller than controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory