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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ccl1tm1Sman
targeted mutation 1, Santos Manes
MGI:3809665
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ccl1tm1Sman/Ccl1tm1Sman B6.129-Ccl1tm1Sman MGI:3809669


Genotype
MGI:3809669
hm1
Allelic
Composition		 Ccl1tm1Sman/Ccl1tm1Sman
Genetic
Background		 B6.129-Ccl1tm1Sman
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccl1tm1Sman mutation (0 available); any Ccl1 mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal regulatory T cell physiology ( J:138942 )
• lovastatin administration fails to increase regulatory T cell recruitment to sites of inflammation in a model of delayed-type hypersensitivity
abnormal inflammatory response ( J:138942 )
• mice are refractory to the anti-inflammatory response of the statin drug lovastatin in delayed-type hypersensitivity
• the anti-inflammatory response of lovastatin is dependent on recruitment of T-regulatory cells to sites of inflammation which fails to occur in these mice

hematopoietic system
abnormal regulatory T cell physiology ( J:138942 )
• lovastatin administration fails to increase regulatory T cell recruitment to sites of inflammation in a model of delayed-type hypersensitivity




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory