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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Traddtm1.1Mak
targeted mutation 1.1, Tak W Mak
MGI:3809708
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Traddtm1.1Mak/Traddtm1.1Mak either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * FVB/N) MGI:3809719
ht2
 		Traddtm1.1Mak/Tradd+ either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * FVB/N) MGI:3809720


Genotype
MGI:3809719
hm1
Allelic
Composition		 Traddtm1.1Mak/Traddtm1.1Mak
Genetic
Background		 either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * FVB/N)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Traddtm1.1Mak mutation (1 available); any Tradd mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
decreased sensitivity to induced cell death ( J:138824 )
• mouse embryonic fibroblasts (MEFs) are completely resistant to apoptosis mediated by TNF

immune system
abnormal spleen follicular dendritic cell network ( J:138824 )
• mice have no organized follicular dendritic cell network in the spleen
absent spleen germinal center ( J:138824 )
• spleen germinal centers fail to develop upon immunization with sheep red blood cells
decreased circulating interleukin-6 level ( J:138824 )
• mice fail to produce IL-6 in response to I.V. injection of TNF while wild-type mice have dramatic increases in this cytokine 6 hours after injection
decreased interleukin-6 secretion ( J:138824 )
• MEFs produce significantly less IL-6 in vitro than controls when cultured with TNF
decreased inflammatory response ( J:138824 )
• tissue damage that normally occurs at the site of TNF administration fails to happen in these mice
decreased acute inflammation ( J:138824 )
• macrophages produced significantly less TNF when exposed to LPS
• macrophages also produce less TNF in response to the TLR3 agonist poly(I:C)

hematopoietic system
abnormal spleen follicular dendritic cell network ( J:138824 )
• mice have no organized follicular dendritic cell network in the spleen
absent spleen germinal center ( J:138824 )
• spleen germinal centers fail to develop upon immunization with sheep red blood cells

homeostasis/metabolism
decreased circulating interleukin-6 level ( J:138824 )
• mice fail to produce IL-6 in response to I.V. injection of TNF while wild-type mice have dramatic increases in this cytokine 6 hours after injection




Genotype
MGI:3809720
ht2
Allelic
Composition		 Traddtm1.1Mak/Tradd+
Genetic
Background		 either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * FVB/N)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Traddtm1.1Mak mutation (1 available); any Tradd mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased acute inflammation ( J:138824 )
• macrophages produced significantly less TNF when exposed to LPS
• macrophages also produce less TNF in response to the TLR3 agonist poly(I:C)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory