About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gt(ROSA)26Sortm5(Map3k14)Rsky
targeted mutation 5, Klaus Rajewsky
MGI:3809722
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Cd19tm1(cre)Cgn/Cd19+
Gt(ROSA)26Sortm5(Map3k14)Rsky/Gt(ROSA)26Sortm5(Map3k14)Rsky 		involves: 129P2/OlaHsd * C57BL/6 MGI:3809748
cn2
 		Cd19tm1(cre)Cgn/Cd19+
Gt(ROSA)26Sortm5(Map3k14)Rsky/Gt(ROSA)26Sortm5(Map3k14)Rsky
Tnfrsf13ctm1Mass/Tnfrsf13ctm1Mass 		involves: 129P2/OlaHsd * C57BL/6 MGI:3809750


Genotype
MGI:3809748
cn1
Allelic
Composition		 Cd19tm1(cre)Cgn/Cd19+
Gt(ROSA)26Sortm5(Map3k14)Rsky/Gt(ROSA)26Sortm5(Map3k14)Rsky
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Gt(ROSA)26Sortm5(Map3k14)Rsky mutation (1 available); any Gt(ROSA)26Sor mutation (994 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased mature B cell number ( J:139293 )
• the number of mature peripheral B cells is increased resulting enlargement of the spleen and lymph nodes
• however, B cell proliferation is normal

hematopoietic system
increased mature B cell number ( J:139293 )
• the number of mature peripheral B cells is increased resulting enlargement of the spleen and lymph nodes
• however, B cell proliferation is normal

growth/size/body
enlarged spleen ( J:139293 )




Genotype
MGI:3809750
cn2
Allelic
Composition		 Cd19tm1(cre)Cgn/Cd19+
Gt(ROSA)26Sortm5(Map3k14)Rsky/Gt(ROSA)26Sortm5(Map3k14)Rsky
Tnfrsf13ctm1Mass/Tnfrsf13ctm1Mass
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Gt(ROSA)26Sortm5(Map3k14)Rsky mutation (1 available); any Gt(ROSA)26Sor mutation (994 available)
Tnfrsf13ctm1Mass mutation (1 available); any Tnfrsf13c mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system

hematopoietic system




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory