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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gt(ROSA)26Sortm6(Map3k14*)Rsky
targeted mutation 6, Klaus Rajewsky
MGI:3809723
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Cd19tm1(cre)Cgn/Cd19+
Gt(ROSA)26Sortm6(Map3k14*)Rsky/Gt(ROSA)26Sortm6(Map3k14*)Rsky 		involves: 129P2/OlaHsd * C57BL/6 MGI:3809749
cn2
 		Cd19tm1(cre)Cgn/Cd19+
Gt(ROSA)26Sortm6(Map3k14*)Rsky/Gt(ROSA)26Sortm6(Map3k14*)Rsky
Tnfrsf13ctm1Mass/Tnfrsf13ctm1Mass 		involves: 129P2/OlaHsd * C57BL/6 MGI:3809751


Genotype
MGI:3809749
cn1
Allelic
Composition		 Cd19tm1(cre)Cgn/Cd19+
Gt(ROSA)26Sortm6(Map3k14*)Rsky/Gt(ROSA)26Sortm6(Map3k14*)Rsky
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Gt(ROSA)26Sortm6(Map3k14*)Rsky mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased B-1 B cell number ( J:139293 )
• in the peritoneal cavity
increased mature B cell number ( J:139293 )
• the spleen contains 6-fold more AA4.1-B cells than in control mice due to enhanced survival
• however, B cell proliferation is normal
abnormal Peyer's patch morphology ( J:139293 )
• lymphoid cells appear to spill over their normal confines into surrounding tissue unlike in wild-type mice

hematopoietic system
decreased B-1 B cell number ( J:139293 )
• in the peritoneal cavity
increased mature B cell number ( J:139293 )
• the spleen contains 6-fold more AA4.1-B cells than in control mice due to enhanced survival
• however, B cell proliferation is normal

growth/size/body
enlarged spleen ( J:139293 )




Genotype
MGI:3809751
cn2
Allelic
Composition		 Cd19tm1(cre)Cgn/Cd19+
Gt(ROSA)26Sortm6(Map3k14*)Rsky/Gt(ROSA)26Sortm6(Map3k14*)Rsky
Tnfrsf13ctm1Mass/Tnfrsf13ctm1Mass
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Gt(ROSA)26Sortm6(Map3k14*)Rsky mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
Tnfrsf13ctm1Mass mutation (1 available); any Tnfrsf13c mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system

hematopoietic system




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory