Phenotypes associated with this allele

• Allele Symbol: Apobec3^Rfv3-r
• Allele Name: recovery from Friend virus 3, resistant
• Allele ID: MGI:3809767
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Apobec3^Rfv3-r/Apobec3^+	(B10.A x A)F1	MGI:3810821

Genotype
MGI:3810821

ht1

• Allelic Composition: Apobec3^Rfv3-r/Apobec3⁺
• Genetic Background: (B10.A x A)F1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:6147 , J:6261 , J:41946 )

N • reduced virus titers by 35-37 days after infection in most mice (J:6147)

N • recover from viremia (J:6147)

N • lower viremia and lower spleen virus by 30-90 days after Friend virus infection, also seen in (B10.A x A.By)F1 mice (J:6261)

N • mice recover to near normal spleen size within several weeks of Friend virus infection (J:41946)

decreased susceptibility to Retroviridae infection ( J:6147 )

• cytotoxic anti-FV leukemia cell antibodies present by 35-37 days, first detectable at 21 days

neoplasm

abnormal tumor morphology ( J:6147 )

• friend virus induced cell surface antigen on splenic leukemia cells peaks between 8 and 20 days after infection

• early but not late leukemia spleen cells vulnerable to cytotoxic anti FV leukemia cell antibodies