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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Apobec3Rfv3-s
recovery from Friend virus 3, susceptible
MGI:3809768
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Apobec3Gt(XN450)Byg/Apobec3Rfv3-s
H2b/H2b 		involves: A.BY * C57BL/6 MGI:3809805
cx2
 		Apobec3Gt(XN450)Byg/Apobec3Rfv3-s
H2b/H2d 		involves: BALB/c * C57BL/6 MGI:3809804


Genotype
MGI:3809805
cx1
Allelic
Composition		 Apobec3Gt(XN450)Byg/Apobec3Rfv3-s
H2b/H2b
Genetic
Background		 involves: A.BY * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apobec3Gt(XN450)Byg mutation (3 available); any Apobec3 mutation (127 available)
Apobec3Rfv3-s mutation (1 available); any Apobec3 mutation (127 available)
H2b mutation (30 available); any H2 mutation (282 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal immunoglobulin level ( J:138778 )
• the levels of neutralizing antibody produced to Friend virus 28 days after inoculation is over an order of magnitude lower than in littermate controls

hematopoietic system
abnormal immunoglobulin level ( J:138778 )
• the levels of neutralizing antibody produced to Friend virus 28 days after inoculation is over an order of magnitude lower than in littermate controls




Genotype
MGI:3809804
cx2
Allelic
Composition		 Apobec3Gt(XN450)Byg/Apobec3Rfv3-s
H2b/H2d
Genetic
Background		 involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apobec3Gt(XN450)Byg mutation (3 available); any Apobec3 mutation (127 available)
Apobec3Rfv3-s mutation (1 available); any Apobec3 mutation (127 available)
H2b mutation (30 available); any H2 mutation (282 available)
H2d mutation (23 available); any H2 mutation (282 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased susceptibility to Retroviridae infection induced morbidity/mortality ( J:138778 )
• less than 40% of mice survive viral infection when infected with 140 spleen focus forming units of Friend virus compared to 90% survival in littermate controls

immune system
abnormal immunoglobulin level ( J:138778 )
• the levels of neutralizing antibody produced to Friend virus 28 days after inoculation is over an order of magnitude lower than in controls
increased susceptibility to Retroviridae infection ( J:138778 )
• 16-week old mice mice infected with Friend virus have an order of magnitude more virus in their blood 8 days later than in littermate controls
• less than 40% of mice survive viral infection when infected with 140 spleen focus forming units of Friend virus compared to 90% survival in littermate controls
increased susceptibility to Retroviridae infection induced morbidity/mortality ( J:138778 )
• less than 40% of mice survive viral infection when infected with 140 spleen focus forming units of Friend virus compared to 90% survival in littermate controls

hematopoietic system
abnormal immunoglobulin level ( J:138778 )
• the levels of neutralizing antibody produced to Friend virus 28 days after inoculation is over an order of magnitude lower than in controls




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory