Phenotypes associated with this allele

• Allele Symbol: Psmc1^tm1.1Maye
• Allele Name: targeted mutation 1.1, R John Mayer
• Allele ID: MGI:3809771
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Psmc1^tm1.1Maye/Psmc1^tm1.1Maye	involves: 129 * CD-1	MGI:3809772
cn2	Psmc1^tm1Maye/Psmc1^tm1.1Maye Th^tm1(cre)Te/Th^+	involves: 129X1/SvJ * CD-1	MGI:3809797

Genotype
MGI:3809772

hm1

• Allelic Composition: Psmc1^tm1.1Maye/Psmc1^tm1.1Maye
• Genetic Background: involves: 129 * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:138991 )

• the authors state homozygous mice are embryonic lethal, however no data are shown

Genotype
MGI:3809797

cn2

• Allelic Composition: Psmc1^tm1Maye/Psmc1^tm1.1Maye; Th^tm1(cre)Te/Th⁺
• Genetic Background: involves: 129X1/SvJ * CD-1

mortality/aging

postnatal lethality ( J:138991 )

• phenotype is identical to the mouse having Psmc1^tm1Maye/Psmc1^tm1.1Maye; Th^tm1(cre)Te/Th⁺

growth/size/body

decreased body size ( J:138991 )

nervous system

gliosis ( J:138991 )

neuron degeneration ( J:138991 )

alpha-synuclein inclusion body ( J:138991 )

homeostasis/metabolism

decreased dopamine level ( J:138991 )

abnormal noradrenaline level ( J:138991 )