All Phenotypes Psmc1<tm1.1Maye> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Psmc1^tm1.1Maye
targeted mutation 1.1, R John Mayer
MGI:3809771

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Psmc1^tm1.1Maye/Psmc1^tm1.1Maye	involves: 129 * CD-1	MGI:3809772
cn2	Psmc1^tm1Maye/Psmc1^tm1.1Maye Th^tm1(cre)Te/Th⁺	involves: 129X1/SvJ * CD-1	MGI:3809797

Allelic Composition	Psmc1^tm1.1Maye/Psmc1^tm1.1Maye
Genetic Background	involves: 129 * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psmc1^tm1.1Maye mutation (0 available); any Psmc1 mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:138991 )

• the authors state homozygous mice are embryonic lethal, however no data are shown

Allelic Composition	Psmc1^tm1Maye/Psmc1^tm1.1Maye Th^tm1(cre)Te/Th⁺
Genetic Background	involves: 129X1/SvJ * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psmc1^tm1.1Maye mutation (0 available); any Psmc1 mutation (19 available)
Psmc1^tm1Maye mutation (0 available); any Psmc1 mutation (19 available)
Th^tm1(cre)Te mutation (1 available); any Th mutation (57 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality ( J:138991 )

• phenotype is identical to the mouse having Psmc1^tm1Maye/Psmc1^tm1.1Maye; Th^tm1(cre)Te/Th⁺

growth/size/body

decreased body size ( J:138991 )

nervous system

gliosis ( J:138991 )

neuron degeneration ( J:138991 )

alpha-synuclein inclusion body ( J:138991 )

homeostasis/metabolism

decreased dopamine level ( J:138991 )

abnormal noradrenaline level ( J:138991 )

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