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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dlx6tm1Jlr
targeted mutation 1, John Rubenstein
MGI:3809858
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Dlx6tm1Jlr/Dlx6tm1Jlr Not Specified MGI:3809892
cx2
 		Dlx1tm1Jlr/Dlx1tm1Jlr
Dlx6tm1Jlr/Dlx6tm1Jlr 		involves: 129X1/SvJ MGI:3809893
cx3
 		Dlx2tm1Jlr/Dlx2tm1Jlr
Dlx6tm1Jlr/Dlx6tm1Jlr 		involves: 129X1/SvJ MGI:3809894


Genotype
MGI:3809892
hm1
Allelic
Composition		 Dlx6tm1Jlr/Dlx6tm1Jlr
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dlx6tm1Jlr mutation (1 available); any Dlx6 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:139700 )
• mice die within a day of birth due to aerophagia

craniofacial
craniofacial phenotype ( J:139700 )
N
• unlike in Dlx6/Dlx5tm1Tlu homozygotes, the nasal and otic capsule are normal
mandibular condyloid process hypoplasia ( J:139700 )
• the mandibular condylar process is hypoplastic
absent mandibular coronoid process ( J:139700 )
• the dentary lacks the coronoid process
small mandible ( J:139700 )
• the mandible is slightly reduced such that the dentary lacks the coronoid process and has a hypoplastic condylar process
abnormal gonial bone morphology ( J:139700 )
• the gonial bone is attached to an ectopic piece (named os paradoxicum) of bone extending towards the ala temporalis

hearing/vestibular/ear
abnormal gonial bone morphology ( J:139700 )
• the gonial bone is attached to an ectopic piece (named os paradoxicum) of bone extending towards the ala temporalis
decreased tympanic ring size ( J:139700 )
• the ectotympanic of the ear is shortened

skeleton
mandibular condyloid process hypoplasia ( J:139700 )
• the mandibular condylar process is hypoplastic
absent mandibular coronoid process ( J:139700 )
• the dentary lacks the coronoid process
small mandible ( J:139700 )
• the mandible is slightly reduced such that the dentary lacks the coronoid process and has a hypoplastic condylar process
abnormal gonial bone morphology ( J:139700 )
• the gonial bone is attached to an ectopic piece (named os paradoxicum) of bone extending towards the ala temporalis

digestive/alimentary system
aerophagia ( J:139700 )
• mice die within a day of birth due to aerophagia




Genotype
MGI:3809893
cx2
Allelic
Composition		 Dlx1tm1Jlr/Dlx1tm1Jlr
Dlx6tm1Jlr/Dlx6tm1Jlr
Genetic
Background		 involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dlx1tm1Jlr mutation (1 available); any Dlx1 mutation (21 available)
Dlx6tm1Jlr mutation (1 available); any Dlx6 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
abnormal cranium morphology ( J:139700 )
• the ventrolateral side of the skull exhibits a duplicate lamina obturans beside the endogenous one
abnormal pterygoid bone morphology ( J:139700 )
• unlike in wild-type mice, dentaries are shortened, fragmented and bifurcated to become bones resembling the maxilla, jugal and pterygoid
abnormal hyoid bone morphology ( J:139700 )
• mice exhibit an abnormal basihyoid and lesser horn of the hyoid
abnormal mandible morphology ( J:139700 )
• unlike in wild-type mice, dentaries are shortened, fragmented and bifurcated to become bones resembling the maxilla, jugal and pterygoid
abnormal zygomatic bone morphology ( J:139700 )
• unlike in wild-type mice, dentaries are shortened, fragmented and bifurcated to become bones resembling the maxilla, jugal and pterygoid

hearing/vestibular/ear
absent tympanic ring ( J:139700 )
• the ectotympanic is reduced or lost
decreased tympanic ring size ( J:139700 )
• the ectotympanic is reduced or lost

skeleton
abnormal cranium morphology ( J:139700 )
• the ventrolateral side of the skull exhibits a duplicate lamina obturans beside the endogenous one
abnormal pterygoid bone morphology ( J:139700 )
• unlike in wild-type mice, dentaries are shortened, fragmented and bifurcated to become bones resembling the maxilla, jugal and pterygoid
abnormal hyoid bone morphology ( J:139700 )
• mice exhibit an abnormal basihyoid and lesser horn of the hyoid
abnormal mandible morphology ( J:139700 )
• unlike in wild-type mice, dentaries are shortened, fragmented and bifurcated to become bones resembling the maxilla, jugal and pterygoid
abnormal zygomatic bone morphology ( J:139700 )
• unlike in wild-type mice, dentaries are shortened, fragmented and bifurcated to become bones resembling the maxilla, jugal and pterygoid




Genotype
MGI:3809894
cx3
Allelic
Composition		 Dlx2tm1Jlr/Dlx2tm1Jlr
Dlx6tm1Jlr/Dlx6tm1Jlr
Genetic
Background		 involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dlx2tm1Jlr mutation (1 available); any Dlx2 mutation (25 available)
Dlx6tm1Jlr mutation (1 available); any Dlx6 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
abnormal cranium morphology ( J:139700 )
• the ventrolateral side of the skull exhibits a duplicate lamina obturans beside the endogenous one
abnormal pterygoid bone morphology ( J:139700 )
• unlike in wild-type mice, dentaries are shortened, fragmented and bifurcated to become bones resembling the maxilla, jugal and pterygoid
abnormal hyoid bone morphology ( J:139700 )
• mice exhibit an abnormal basihyoid and lesser horn or the hyoid
abnormal mandible morphology ( J:139700 )
• unlike in wild-type mice, dentaries are shortened, fragmented and bifurcated to become bones resembling the maxilla, jugal and pterygoid
abnormal zygomatic bone morphology ( J:139700 )
• unlike in wild-type mice, dentaries are shortened, fragmented and bifurcated to become bones resembling the maxilla, jugal and pterygoid

hearing/vestibular/ear
absent tympanic ring ( J:139700 )
• the ectotympanic is reduced or lost
decreased tympanic ring size ( J:139700 )
• the ectotympanic is reduced or lost

skeleton
abnormal cranium morphology ( J:139700 )
• the ventrolateral side of the skull exhibits a duplicate lamina obturans beside the endogenous one
abnormal pterygoid bone morphology ( J:139700 )
• unlike in wild-type mice, dentaries are shortened, fragmented and bifurcated to become bones resembling the maxilla, jugal and pterygoid
abnormal hyoid bone morphology ( J:139700 )
• mice exhibit an abnormal basihyoid and lesser horn or the hyoid
abnormal mandible morphology ( J:139700 )
• unlike in wild-type mice, dentaries are shortened, fragmented and bifurcated to become bones resembling the maxilla, jugal and pterygoid
abnormal zygomatic bone morphology ( J:139700 )
• unlike in wild-type mice, dentaries are shortened, fragmented and bifurcated to become bones resembling the maxilla, jugal and pterygoid




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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory