Phenotypes associated with this allele

• Allele Symbol: Dnajc24^m1Jkn
• Allele Name: mutation 1, Ian J Jackson
• Allele ID: MGI:3809863
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dnajc24^m1Jkn/Dnajc24^m1Jkn	involves: BALB/c	MGI:3809874
hm2	Dnajc24^m1Jkn/Dnajc24^m1Jkn	involves: BALB/c * C3H/HeH	MGI:3809872

Genotype
MGI:3809874

hm1

• Allelic Composition: Dnajc24^m1Jkn/Dnajc24^m1Jkn
• Genetic Background: involves: BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, incomplete penetrance ( J:139665 )

• Background Sensitivity: homozygotes on an outbred background survive longer and at a higher frequency than homozygotes on a C3H/HeH background, which all die by E14.5

• in at least one case, an embryo survived until birth

limbs/digits/tail

polydactyly ( J:139665 )

• embryos that survived long enough to initiate digit formation show one or more preaxial digits that persist through development

• a rare neonatal homozygote had a total duplication of digit 1 in addition to a partial digit-1 duplication

Genotype
MGI:3809872

hm2

• Allelic Composition: Dnajc24^m1Jkn/Dnajc24^m1Jkn
• Genetic Background: involves: BALB/c * C3H/HeH

mortality/aging

embryonic lethality, complete penetrance ( J:139665 )

• homozygous embryos are present at lower numbers than expected and all of them die by E14.5

growth/size/body

decreased embryo size ( J:139665 )

• reduction in embryo size is first observed at E10.5 with apparent growth deficits persisting until death occurs by E14.5

embryo

decreased embryo size ( J:139665 )

• reduction in embryo size is first observed at E10.5 with apparent growth deficits persisting until death occurs by E14.5