All Phenotypes Rad9a<tm2Lieb> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Rad9a^tm2Lieb/Rad9a^tm2Lieb Tg(KRT5-cre)1Xya/?	involves: 129S/SvEv * C57BL/6	MGI:3809928
cn2	Rad9a^tm2Lieb/Rad9a⁺ Tg(KRT5-cre)1Xya/?	involves: 129S/SvEv * C57BL/6	MGI:3809929

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased skin papilloma incidence ( J:138845 )

• induced by DMBA treatment in about 15 weeks as compared to 27 weeks for wild-type controls

• tumors derived from keratinocytes

• all tumor cells are conditionally deleted

• DMBA painted onto shaved skin 2X per week for 25 weeks

cellular

abnormal cell cycle ( J:138845 )

• cell cycle arrest in late S phase

increased apoptosis ( J:138845 )

• in DMBA treated cells

abnormal double-strand DNA break repair ( J:138845 )

• more double strand breaks than wild-type controls

• DMBA increases double strand breaks

pigmentation

abnormal skin pigmentation ( J:138845 )

• due to DMBA treatment

• in 81% of homozygotes as compared to 13% of wild-type controls

• increased pigmentation within 2-5 weeks of tumor formation

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:138845 )

• more double strand breaks than wild-type controls

• DMBA increases double strand breaks

integument

abnormal skin pigmentation ( J:138845 )

• due to DMBA treatment

• in 81% of homozygotes as compared to 13% of wild-type controls

• increased pigmentation within 2-5 weeks of tumor formation

increased skin papilloma incidence ( J:138845 )

• induced by DMBA treatment in about 15 weeks as compared to 27 weeks for wild-type controls

• tumors derived from keratinocytes

• all tumor cells are conditionally deleted

• DMBA painted onto shaved skin 2X per week for 25 weeks

Allelic Composition	Rad9a^tm2Lieb/Rad9a⁺ Tg(KRT5-cre)1Xya/?
Genetic Background	involves: 129S/SvEv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad9a^tm2Lieb mutation (0 available); any Rad9a mutation (27 available)
Tg(KRT5-cre)1Xya mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased skin papilloma incidence ( J:138845 )

• induced by DMBA treatment in about 25 weeks for heterozygotes compared to 27 weeks for wild-type controls

• tumors derived from keratinocytes

• all tumor cells are conditionally deleted

• DMBA painted onto shaved skin 2X per week for 25 weeks

cellular

abnormal double-strand DNA break repair ( J:138845 )

• more double strand breaks than wild-type controls

pigmentation

abnormal skin pigmentation ( J:138845 )

• in 25% of heterozygotes compared to 13% of wild-type controls

• increased pigmentation within 2-5 weeks of tumor formation

• due to DMBA treatment

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:138845 )

• more double strand breaks than wild-type controls

integument

abnormal skin pigmentation ( J:138845 )

• in 25% of heterozygotes compared to 13% of wild-type controls

• increased pigmentation within 2-5 weeks of tumor formation

• due to DMBA treatment

increased skin papilloma incidence ( J:138845 )

• induced by DMBA treatment in about 25 weeks for heterozygotes compared to 27 weeks for wild-type controls

• tumors derived from keratinocytes

• all tumor cells are conditionally deleted

• DMBA painted onto shaved skin 2X per week for 25 weeks

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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