All Phenotypes Rad9a<tm2Lieb> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Rad9a^tm2Lieb/Rad9a^tm2Lieb Tg(KRT5-cre)1Xya/?	involves: 129S/SvEv * C57BL/6	MGI:3809928
cn2	Rad9a^tm2Lieb/Rad9a⁺ Tg(KRT5-cre)1Xya/?	involves: 129S/SvEv * C57BL/6	MGI:3809929

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased skin papilloma incidence ( J:138845 )

• induced by DMBA treatment in about 15 weeks as compared to 27 weeks for wild-type controls

• tumors derived from keratinocytes

• all tumor cells are conditionally deleted

• DMBA painted onto shaved skin 2X per week for 25 weeks

cellular

abnormal cell cycle ( J:138845 )

• cell cycle arrest in late S phase

increased apoptosis ( J:138845 )

• in DMBA treated cells

abnormal double-strand DNA break repair ( J:138845 )

• more double strand breaks than wild-type controls

• DMBA increases double strand breaks

pigmentation

abnormal skin pigmentation ( J:138845 )

• due to DMBA treatment

• in 81% of homozygotes as compared to 13% of wild-type controls

• increased pigmentation within 2-5 weeks of tumor formation

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:138845 )

• more double strand breaks than wild-type controls

• DMBA increases double strand breaks

integument

abnormal skin pigmentation ( J:138845 )

• due to DMBA treatment

• in 81% of homozygotes as compared to 13% of wild-type controls

• increased pigmentation within 2-5 weeks of tumor formation

increased skin papilloma incidence ( J:138845 )

• induced by DMBA treatment in about 15 weeks as compared to 27 weeks for wild-type controls

• tumors derived from keratinocytes

• all tumor cells are conditionally deleted

• DMBA painted onto shaved skin 2X per week for 25 weeks

Allelic Composition	Rad9a^tm2Lieb/Rad9a⁺ Tg(KRT5-cre)1Xya/?
Genetic Background	involves: 129S/SvEv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad9a^tm2Lieb mutation (0 available); any Rad9a mutation (27 available)
Tg(KRT5-cre)1Xya mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased skin papilloma incidence ( J:138845 )

• induced by DMBA treatment in about 25 weeks for heterozygotes compared to 27 weeks for wild-type controls

• tumors derived from keratinocytes

• all tumor cells are conditionally deleted

• DMBA painted onto shaved skin 2X per week for 25 weeks

cellular

abnormal double-strand DNA break repair ( J:138845 )

• more double strand breaks than wild-type controls

pigmentation

abnormal skin pigmentation ( J:138845 )

• in 25% of heterozygotes compared to 13% of wild-type controls

• increased pigmentation within 2-5 weeks of tumor formation

• due to DMBA treatment

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:138845 )

• more double strand breaks than wild-type controls

integument

abnormal skin pigmentation ( J:138845 )

• in 25% of heterozygotes compared to 13% of wild-type controls

• increased pigmentation within 2-5 weeks of tumor formation

• due to DMBA treatment

increased skin papilloma incidence ( J:138845 )

• induced by DMBA treatment in about 25 weeks for heterozygotes compared to 27 weeks for wild-type controls

• tumors derived from keratinocytes

• all tumor cells are conditionally deleted

• DMBA painted onto shaved skin 2X per week for 25 weeks

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 07/05/2024 MGI 6.24