Phenotypes associated with this allele

• Allele Symbol: Stx1a^tm2.1Sud
• Allele Name: targeted mutation 2.1, Thomas C Sudhof
• Allele ID: MGI:3809921
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Stx1a^tm2.1Sud/Stx1a^tm2.1Sud	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3832396
cx2	Stx1a^tm2.1Sud/Stx1a^tm2.1Sud Stx1b^tm1.1Sud/Stx1b^tm1.1Sud	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3832394

Genotype
MGI:3832396

hm1

• Allelic Composition: Stx1a^tm2.1Sud/Stx1a^tm2.1Sud
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:138035 )

N • homozygotes show no decrease in survival or other obvious phenotypes

Genotype
MGI:3832394

cx2

• Allelic Composition: Stx1a^tm2.1Sud/Stx1a^tm2.1Sud; Stx1b^tm1.1Sud/Stx1b^tm1.1Sud
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

nervous system

abnormal neuron morphology ( J:138035 )

• a 20% increase in size of the postsynaptic density is observed compared to cultured cortical neurons with wild type Stx1a

abnormal synaptic vesicle recycling ( J:138035 )

• about a 25% increase in synaptic vesicle docking at synapses in cultured cortical neurons compared to controls