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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Akap5tm1.1Jsco
targeted mutation 1.1, John D Scott
MGI:3809938
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Akap5tm1.1Jsco/Akap5tm1.1Jsco involves: 129S * C57BL/6 MGI:5448701
hm2
 		Akap5tm1.1Jsco/Akap5tm1.1Jsco involves: 129S * C57BL/6 * FVB/N MGI:3809939


Genotype
MGI:5448701
hm1
Allelic
Composition		 Akap5tm1.1Jsco/Akap5tm1.1Jsco
Genetic
Background		 involves: 129S * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akap5tm1.1Jsco mutation (1 available); any Akap5 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased insulin secretion ( J:190017 )
• from glucose stimulated islets
decreased circulating insulin level ( J:190017 )
• in fasting mice and after intraperitoneal glucose injection
increased insulin sensitivity ( J:190017 )
• in skeletal muscle

endocrine/exocrine glands
abnormal pancreatic beta cell morphology ( J:190017 )
• beta cells exhibit attenuated L-type calcium currents and perturbed glucose-induced calcium flux compared with wild-type cells
decreased insulin secretion ( J:190017 )
• from glucose stimulated islets




Genotype
MGI:3809939
hm2
Allelic
Composition		 Akap5tm1.1Jsco/Akap5tm1.1Jsco
Genetic
Background		 involves: 129S * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akap5tm1.1Jsco mutation (1 available); any Akap5 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased susceptibility to pharmacologically induced seizures ( J:138972 )
• resistant to seizure after peritoneal injection of pilocarpine
• the brains of these animals had no obvious morphological abnormalities
abnormal AMPA-mediated synaptic currents ( J:138972 )
• agonist dependent downregulation of AMPA channel was more pronounced
reduced long-term depression ( J:138972 )
• induction of LTD by low frequency stimulation was markedly reduced

behavior/neurological
decreased susceptibility to pharmacologically induced seizures ( J:138972 )
• resistant to seizure after peritoneal injection of pilocarpine
• the brains of these animals had no obvious morphological abnormalities
abnormal spatial learning ( J:138972 )
• deficits in spatial memory retention
impaired coordination ( J:138972 )
• deficits in motor coordination and strength




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory