About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Kmt5btm1Jnw
targeted mutation 1, Thomas Jenuwein
MGI:3810074
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Kmt5btm1Jnw/Kmt5btm1Jnw
Kmt5ctm1.1Jnw/Kmt5ctm1.1Jnw
Commd10Tg(Vav1-icre)A2Kio/Commd10+ 		involves: 129/Sv * C57BL/6J * C57BL/10 * CBA/Ca MGI:3810116


Genotype
MGI:3810116
cn1
Allelic
Composition		 Kmt5btm1Jnw/Kmt5btm1Jnw
Kmt5ctm1.1Jnw/Kmt5ctm1.1Jnw
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background		 involves: 129/Sv * C57BL/6J * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (3 available); any Commd10 mutation (24 available)
Kmt5btm1Jnw mutation (0 available); any Kmt5b mutation (43 available)
Kmt5ctm1.1Jnw mutation (0 available); any Kmt5c mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:139510 )
N
• V(D)J recombination in B and T cells is normal
abnormal lymphopoiesis ( J:139510 )
• in a competitive reconstitution assay, cells fail to repopulate the B and T cell population as well as do wild type cells
abnormal class switch recombination ( J:139510 )
• fewer cells undergo the switch from IgM to IgG1 or IgG3 compared to in wild type mice
• however, there is no increase in Igh chromosomal aberrations
decreased B cell number ( J:139510 )
• the number of mature and re-circulating B cells is decreased compared to in wild-type mice
• however, the numbers of pro- and pre-B cells is normal

hematopoietic system
abnormal lymphopoiesis ( J:139510 )
• in a competitive reconstitution assay, cells fail to repopulate the B and T cell population as well as do wild type cells
abnormal class switch recombination ( J:139510 )
• fewer cells undergo the switch from IgM to IgG1 or IgG3 compared to in wild type mice
• however, there is no increase in Igh chromosomal aberrations
decreased B cell number ( J:139510 )
• the number of mature and re-circulating B cells is decreased compared to in wild-type mice
• however, the numbers of pro- and pre-B cells is normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory