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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Kmt5btm1.1Jnw
targeted mutation 1.1, Thomas Jenuwein
MGI:3810075
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Kmt5btm1.1Jnw/Kmt5btm1.1Jnw involves: 129 * C57BL/6J MGI:3810111
cx2
 		Kmt5btm1.1Jnw/Kmt5btm1.1Jnw
Kmt5ctm1.1Jnw/Kmt5ctm1.1Jnw 		involves: 129 * C57BL/6J MGI:3810112


Genotype
MGI:3810111
hm1
Allelic
Composition		 Kmt5btm1.1Jnw/Kmt5btm1.1Jnw
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kmt5btm1.1Jnw mutation (0 available); any Kmt5b mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Small size of Kmt5btm1.1Jnw/Kmt5btm1.1Jnw and Kmt5btm1.1Jnw/Kmt5btm1.1Jnw Kmt5ctm1.1Jnw/Kmt5ctm1.1Jnw mice

mortality/aging
neonatal lethality, complete penetrance ( J:139510 )
• mice die within hours of birth probably due to alveolar defects
prenatal lethality, incomplete penetrance ( J:139510 )
• fewer than expected mice are born

growth/size/body
decreased body size ( J:139510 )
• at birth

respiratory system
abnormal pulmonary alveolus morphology ( J:139510 )
• mice die within hours of birth probably due to alveolar defects




Genotype
MGI:3810112
cx2
Allelic
Composition		 Kmt5btm1.1Jnw/Kmt5btm1.1Jnw
Kmt5ctm1.1Jnw/Kmt5ctm1.1Jnw
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kmt5btm1.1Jnw mutation (0 available); any Kmt5b mutation (43 available)
Kmt5ctm1.1Jnw mutation (0 available); any Kmt5c mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Small size of Kmt5btm1.1Jnw/Kmt5btm1.1Jnw and Kmt5btm1.1Jnw/Kmt5btm1.1Jnw Kmt5ctm1.1Jnw/Kmt5ctm1.1Jnw mice

mortality/aging
neonatal lethality, complete penetrance ( J:139510 )
• mice die within hours of birth probably due to alveolar defects
prenatal lethality, incomplete penetrance ( J:139510 )
• fewer than expected mice are born

cellular
abnormal cell cycle ( J:139510 )
• mouse embryonic fibroblasts exhibit delayed entry into S phase compared to wild-type cells
decreased fibroblast proliferation ( J:139510 )
• mouse embryonic fibroblasts exhibit reduced proliferation and reach plateau sooner compared to wild-type cells
early cellular replicative senescence ( J:139510 )
• mouse embryonic fibroblasts cease replicating sooner than in wild-type cells
abnormal DNA repair ( J:139510 )
• mouse embryonic fibroblasts exhibit increased accumulation of DNA damage following treatment with gamma radiation compared to in similarly treated wild-type cells
• however, the DNA of mouse embryonic fibroblasts exhibit normal sensitivity to DNA damage

growth/size/body
decreased body size ( J:139510 )
• at birth

respiratory system
abnormal pulmonary alveolus morphology ( J:139510 )
• mice die within hours of birth probably due to alveolar defects

homeostasis/metabolism
abnormal DNA repair ( J:139510 )
• mouse embryonic fibroblasts exhibit increased accumulation of DNA damage following treatment with gamma radiation compared to in similarly treated wild-type cells
• however, the DNA of mouse embryonic fibroblasts exhibit normal sensitivity to DNA damage




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory