All Phenotypes Kmt5c<tm1.1Jnw> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kmt5c^tm1.1Jnw/Kmt5c^tm1.1Jnw	involves: 129 * C57BL/6J	MGI:3810114
cn2	Kmt5b^tm1Jnw/Kmt5b^tm1Jnw Kmt5c^tm1.1Jnw/Kmt5c^tm1.1Jnw Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺	involves: 129/Sv * C57BL/6J * C57BL/10 * CBA/Ca	MGI:3810116
cx3	Kmt5b^tm1.1Jnw/Kmt5b^tm1.1Jnw Kmt5c^tm1.1Jnw/Kmt5c^tm1.1Jnw	involves: 129 * C57BL/6J	MGI:3810112

Allelic Composition	Kmt5c^tm1.1Jnw/Kmt5c^tm1.1Jnw
Genetic Background	involves: 129 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kmt5c^tm1.1Jnw mutation (0 available); any Kmt5c mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:139510 )

• mice exhibit no defects

Allelic Composition	Kmt5b^tm1Jnw/Kmt5b^tm1Jnw Kmt5c^tm1.1Jnw/Kmt5c^tm1.1Jnw Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
Genetic Background	involves: 129/Sv * C57BL/6J * C57BL/10 * CBA/Ca

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10^{Tg(Vav1-icre)A2Kio} mutation (3 available); any Commd10 mutation (24 available)
Kmt5b^tm1Jnw mutation (0 available); any Kmt5b mutation (43 available)
Kmt5c^tm1.1Jnw mutation (0 available); any Kmt5c mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:139510 )

N	• V(D)J recombination in B and T cells is normal

abnormal lymphopoiesis ( J:139510 )

• in a competitive reconstitution assay, cells fail to repopulate the B and T cell population as well as do wild type cells

abnormal class switch recombination ( J:139510 )

• fewer cells undergo the switch from IgM to IgG1 or IgG3 compared to in wild type mice

• however, there is no increase in Igh chromosomal aberrations

decreased double-positive T cell number ( J:139510 )

• in the thymus

decreased B cell number ( J:139510 )

• the number of mature and re-circulating B cells is decreased compared to in wild-type mice

• however, the numbers of pro- and pre-B cells is normal

hematopoietic system

abnormal lymphopoiesis ( J:139510 )

• in a competitive reconstitution assay, cells fail to repopulate the B and T cell population as well as do wild type cells

abnormal class switch recombination ( J:139510 )

• fewer cells undergo the switch from IgM to IgG1 or IgG3 compared to in wild type mice

• however, there is no increase in Igh chromosomal aberrations

decreased double-positive T cell number ( J:139510 )

• in the thymus

decreased B cell number ( J:139510 )

• the number of mature and re-circulating B cells is decreased compared to in wild-type mice

• however, the numbers of pro- and pre-B cells is normal

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Small size of Kmt5b^tm1.1Jnw/Kmt5b^tm1.1Jnw and Kmt5b^tm1.1Jnw/Kmt5b^tm1.1Jnw Kmt5c^tm1.1Jnw/Kmt5c^tm1.1Jnw mice

mortality/aging

neonatal lethality, complete penetrance ( J:139510 )

• mice die within hours of birth probably due to alveolar defects

prenatal lethality, incomplete penetrance ( J:139510 )

• fewer than expected mice are born

cellular

abnormal cell cycle ( J:139510 )

• mouse embryonic fibroblasts exhibit delayed entry into S phase compared to wild-type cells

increased cellular sensitivity to hydroxyurea ( J:139510 )

increased cellular sensitivity to ultraviolet irradiation ( J:139510 )

decreased fibroblast proliferation ( J:139510 )

• mouse embryonic fibroblasts exhibit reduced proliferation and reach plateau sooner compared to wild-type cells

early cellular replicative senescence ( J:139510 )

• mouse embryonic fibroblasts cease replicating sooner than in wild-type cells

abnormal DNA repair ( J:139510 )

• mouse embryonic fibroblasts exhibit increased accumulation of DNA damage following treatment with gamma radiation compared to in similarly treated wild-type cells

• however, the DNA of mouse embryonic fibroblasts exhibit normal sensitivity to DNA damage

growth/size/body

decreased body size ( J:139510 )

• at birth

respiratory system

abnormal pulmonary alveolus morphology ( J:139510 )

• mice die within hours of birth probably due to alveolar defects

homeostasis/metabolism

abnormal DNA repair ( J:139510 )

• mouse embryonic fibroblasts exhibit increased accumulation of DNA damage following treatment with gamma radiation compared to in similarly treated wild-type cells

• however, the DNA of mouse embryonic fibroblasts exhibit normal sensitivity to DNA damage

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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