All Phenotypes Tg(IGH@yH2CM)2Amgn MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(IGH@yH2CM)2Amgn
transgene insertion 2, Amgen
MGI:3810127

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Igh-J^tm1Jkbv/Igh-J^tm1Jkbv Igkc^tm1Jkbv/Igkc^tm1Jkbv Tg(IGH@yH2CM)2Amgn/0 Tg(IGK@yK2)J23.1Jkbv/0	involves: 129P2/OlaHsd	MGI:3810269

Allelic Composition	Igh-J^tm1Jkbv/Igh-J^tm1Jkbv Igkc^tm1Jkbv/Igkc^tm1Jkbv Tg(IGH@yH2CM)2Amgn/0 Tg(IGK@yK2)J23.1Jkbv/0
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-J^tm1Jkbv mutation (0 available); any Igh-J mutation (13 available)
Igkc^tm1Jkbv mutation (0 available); any Igkc mutation (9 available)
Tg(IGH@yH2CM)2Amgn mutation (0 available)
Tg(IGK@yK2)J23.1Jkbv mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased B cell number ( J:139792 )

• mice have 80-100% the number of B cells as wild-type mice

abnormal immunoglobulin level ( J:139792 )

• unimmunized mice produce significant levels of human IgM and IgG2

• IgM levels in sera ranged from 27.3-109.4 micrograms/ml

• IgG2 levels in sera ranged from 37.6-665.3 micrograms/ml

• immunizing mice with human antigens leads to production of antigen-specific antibodies with human sequences

hematopoietic system