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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(IGH@yHG4)1Amgn
transgene insertion 1, Amgen
MGI:3810130
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Igh-Jtm1Jkbv/Igh-Jtm1Jkbv
Igkctm1Jkbv/Igkctm1Jkbv
Tg(IGH@yHG4)1Amgn/0
Tg(IGK@yK2)J23.1Jkbv/0 		involves: 129P2/OlaHsd MGI:3810271


Genotype
MGI:3810271
cx1
Allelic
Composition		 Igh-Jtm1Jkbv/Igh-Jtm1Jkbv
Igkctm1Jkbv/Igkctm1Jkbv
Tg(IGH@yHG4)1Amgn/0
Tg(IGK@yK2)J23.1Jkbv/0
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-Jtm1Jkbv mutation (0 available); any Igh-J mutation (13 available)
Igkctm1Jkbv mutation (0 available); any Igkc mutation (9 available)
Tg(IGH@yHG4)1Amgn mutation (0 available)
Tg(IGK@yK2)J23.1Jkbv mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal immunoglobulin level ( J:139792 )
• immunizing mice with human antigens leads to production of antigen-specific IgG4 antibodies with human sequences

hematopoietic system
abnormal immunoglobulin level ( J:139792 )
• immunizing mice with human antigens leads to production of antigen-specific IgG4 antibodies with human sequences




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory