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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Stra8tm1.1Nbg
targeted mutation 1.1, Norbert B Ghyselinck
MGI:3810145
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Stra8tm1.1Nbg/Stra8tm1.1Nbg involves: 129S2/SvPas * C57BL/6 MGI:3810148


Genotype
MGI:3810148
hm1
Allelic
Composition		 Stra8tm1.1Nbg/Stra8tm1.1Nbg
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stra8tm1.1Nbg mutation (0 available); any Stra8 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
absent oocytes ( J:139646 )
• at 8 weeks of age
azoospermia ( J:139646 )
• male mice lack post-meiotic germ cells
abnormal male meiosis ( J:139646 )
• assembly of the synaptonemal complex is impaired and meiotic recombination in sperm does not occur
• during meiosis, many spermatocytes exhibit premature chromosome condensation unlike in wild-type sperm
• during metaphase, spermatocytes form 40 univalent chromosomes instead of form 19 bivalents (plus X and Y) unlike in wild-type sperm
arrest of male meiosis ( J:139646 )
• despite spermatocytes entering into DNA replication and meiosis, mice possess mostly preleptotene spermatocytes
absent mature ovarian follicles ( J:139646 )
• at 8 weeks of age

endocrine/exocrine glands
absent mature ovarian follicles ( J:139646 )
• at 8 weeks of age

cellular
absent oocytes ( J:139646 )
• at 8 weeks of age
azoospermia ( J:139646 )
• male mice lack post-meiotic germ cells
abnormal male meiosis ( J:139646 )
• assembly of the synaptonemal complex is impaired and meiotic recombination in sperm does not occur
• during meiosis, many spermatocytes exhibit premature chromosome condensation unlike in wild-type sperm
• during metaphase, spermatocytes form 40 univalent chromosomes instead of form 19 bivalents (plus X and Y) unlike in wild-type sperm
arrest of male meiosis ( J:139646 )
• despite spermatocytes entering into DNA replication and meiosis, mice possess mostly preleptotene spermatocytes




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory