All Phenotypes Sfrp2<tm1Ktas> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Sfrp2^tm1Ktas
targeted mutation 1, Kei Tashiro
MGI:3810257

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sfrp2^tm1Ktas/Sfrp2^tm1Ktas	involves: 129X1/SvJ	MGI:3810258
hm2	Sfrp2^tm1Ktas/Sfrp2^tm1Ktas	involves: 129X1/SvJ * C57BL/6	MGI:3810262
hm3	Sfrp2^tm1Ktas/Sfrp2^tm1Ktas	involves: 129X1/SvJ * CBA/N	MGI:3810260
ht4	Sfrp2^tm1Ktas/Sfrp2⁺	involves: 129X1/SvJ	MGI:3810259
ht5	Sfrp2^tm1Ktas/Sfrp2⁺	involves: 129X1/SvJ * C57BL/6	MGI:3810263
ht6	Sfrp2^tm1Ktas/Sfrp2⁺	involves: 129X1/SvJ * CBA/N	MGI:3810261

Allelic Composition	Sfrp2^tm1Ktas/Sfrp2^tm1Ktas
Genetic Background	involves: 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sfrp2^tm1Ktas mutation (0 available); any Sfrp2 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

syndactyly ( J:138805 )

• Background Sensitivity: penetrance is higher (about 96%) compared to homozygotes on a mixed 129X1/SvJ and C57BL/6 background

• hindlimbs are more severely affected than forelimbs but webbing is symmetrical between the left and right side

• penetration rate of webbing is highest for the interdigital spaces 2 and 3

• however, unlike mice on a mixed 129X1/SvJ and C57BL/6 background synpolydactyly is not seen

abnormal digit development ( J:138805 )

• at E13.5 maturation of the digital analgen is disrupted and fused digital rays of presumptive phalanges are seen

abnormal interdigital cell death ( J:138805 )

• at E14 programmed cell death in the proximal portion of the interdigit zone is severely diminished and shallow grooves appear in the distal but not the proximal portion of the interdigital zone

abnormal caudal vertebrae morphology ( J:138805 )

• tail kinks result from perturbed growth of the vertebral bones

kinked tail ( J:138805 )

• variable penetrance and variable severity

skeleton

abnormal caudal vertebrae morphology ( J:138805 )

• tail kinks result from perturbed growth of the vertebral bones

abnormal vertebral epiphyseal plate morphology ( J:138805 )

• in caudal vertebrae growth plates chondrocyte differentiation is impaired

cellular

abnormal interdigital cell death ( J:138805 )

• at E14 programmed cell death in the proximal portion of the interdigit zone is severely diminished and shallow grooves appear in the distal but not the proximal portion of the interdigital zone

Allelic Composition	Sfrp2^tm1Ktas/Sfrp2^tm1Ktas
Genetic Background	involves: 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sfrp2^tm1Ktas mutation (0 available); any Sfrp2 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

syndactyly ( J:138805 )

• hindlimbs are more severely affected than forelimbs and the webbing phenotype displays right side dominance

• interdigital space 1 is most severely affected and is accompanied by preaxial synpolydactyly

• Background Sensitivity: penetrance is lower (about 12%) compared to homozygotes on a 129X1/SvJ or mixed 129X1/SvJ and CBA/N background

polysyndactyly ( J:138805 )

• Background Sensitivity: preaxial synpolydactyly is seen in 15% of mice on this background but not in mice on either a 129X1/SvJ or mixed 129X1/SvJ and CBA/N background

• preaxial synpolydactyly is often unilateral with a right side dominance and accompanied by syndactyly

abnormal digit development ( J:138805 )

• at E13.5 maturation of the digital analgen is disrupted and fused digital rays of presumptive phalanges are seen

abnormal interdigital cell death ( J:138805 )

• at E14 programmed cell death in the proximal portion of the interdigit zone is severely diminished and shallow grooves appear in the distal but not the proximal portion of the interdigital zone

abnormal caudal vertebrae morphology ( J:138805 )

• tail kinks result from perturbed growth of the vertebral bones

kinked tail ( J:138805 )

• variable penetrance and variable severity

skeleton

abnormal caudal vertebrae morphology ( J:138805 )

• tail kinks result from perturbed growth of the vertebral bones

abnormal vertebral epiphyseal plate morphology ( J:138805 )

• in caudal vertebrae growth plates chondrocyte differentiation is impaired

cellular

abnormal interdigital cell death ( J:138805 )

• at E14 programmed cell death in the proximal portion of the interdigit zone is severely diminished and shallow grooves appear in the distal but not the proximal portion of the interdigital zone

Allelic Composition	Sfrp2^tm1Ktas/Sfrp2^tm1Ktas
Genetic Background	involves: 129X1/SvJ * CBA/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sfrp2^tm1Ktas mutation (0 available); any Sfrp2 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

syndactyly ( J:138805 )

• hindlimbs are more severely affected than forelimbs but webbing is symmetrical between the left and right side

• penetration rate of webbing is highest for the interdigital spaces 2 and 3

• Background Sensitivity: penetrance is higher (about 95%) compared to homozygotes on a mixed 129X1/SvJ and C57BL/6 background

• however, unlike mice on a mixed 129X1/SvJ and C57BL/6 background synpolydactyly is not seen

abnormal digit development ( J:138805 )

• at E13.5 maturation of the digital analgen is disrupted and fused digital rays of presumptive phalanges are seen

abnormal interdigital cell death ( J:138805 )

• at E14 programmed cell death in the proximal portion of the interdigit zone is severely diminished and shallow grooves appear in the distal but not the proximal portion of the interdigital zone

abnormal caudal vertebrae morphology ( J:138805 )

• tail kinks result from perturbed growth of the vertebral bones

kinked tail ( J:138805 )

• variable penetrance and variable severity

skeleton

abnormal caudal vertebrae morphology ( J:138805 )

• tail kinks result from perturbed growth of the vertebral bones

abnormal vertebral epiphyseal plate morphology ( J:138805 )

• in caudal vertebrae growth plates chondrocyte differentiation is impaired

cellular

abnormal interdigital cell death ( J:138805 )

• at E14 programmed cell death in the proximal portion of the interdigit zone is severely diminished and shallow grooves appear in the distal but not the proximal portion of the interdigital zone

Allelic Composition	Sfrp2^tm1Ktas/Sfrp2⁺
Genetic Background	involves: 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sfrp2^tm1Ktas mutation (0 available); any Sfrp2 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

syndactyly ( J:138805 )

• interdigital space 2 is less severely affected than interdigital space 3

• webbing is symmetrical between the left and right side

• Background Sensitivity: penetrance is higher (about 59%) compared to heterozygotes on a mixed 129X1/SvJ and C57BL/6 background

Allelic Composition	Sfrp2^tm1Ktas/Sfrp2⁺
Genetic Background	involves: 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sfrp2^tm1Ktas mutation (0 available); any Sfrp2 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

limbs/digits/tail phenotype ( J:138805 )

N	• Background Sensitivity: unlike mice on a 129X1/SvJ or mixed 129X1/SvJ and CBA/N background syndactyly is not seen

Allelic Composition	Sfrp2^tm1Ktas/Sfrp2⁺
Genetic Background	involves: 129X1/SvJ * CBA/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sfrp2^tm1Ktas mutation (0 available); any Sfrp2 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

syndactyly ( J:138805 )

• interdigital space 2 is less severely affected than interdigital space 3

• webbing is symmetrical between the left and right side

• Background Sensitivity: penetrance is higher (about 24%) compared to heterozygotes on a mixed 129X1/SvJ and C57BL/6 background

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