All Phenotypes Cacna1a<tm1Hzo> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cacna1a^tm1Hzo
targeted mutation 1, Huda Y Zoghbi
MGI:3810386

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cacna1a^tm1Hzo/Cacna1a^tm1Hzo	involves: 129S/SvEv	MGI:3810399

Allelic Composition	Cacna1a^tm1Hzo/Cacna1a^tm1Hzo
Genetic Background	involves: 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cacna1a^tm1Hzo mutation (1 available); any Cacna1a mutation (118 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal channel response ( J:139488 )

• barium current density of the calcium ion channel is decrease compared to in wild-type cells likely due to decreased calcium ion channel abundance

• however, voltage dependent activation and inactivation of the calcium ion channel is normal

behavior/neurological

behavior/neurological phenotype ( J:139488 )

N	• mice exhibit normal behavior beyond 20 months of age

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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