Analysis Tools
mortality/aging
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• half the mice die from systemic autoimmune disease by one year of age
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growth/size/body
weight loss
(
J:139785
)
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• mice lose weight as result of autoimmune disease, with mice weighing about 20% less than controls at 4 months of age
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• spleens are increased in weight by about 50% at 4 months of age
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• there is about a 50% increase in the number of cells found in the spleen at 4 months of age
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immune system
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• B cell numbers in the spleen of 4-month old mice are increased by about half
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• T cell numbers in the spleen of 4-month old mice are increased by about half
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• CD11b+ cells in the spleen of 4-month old mice are increased by more than half
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• both CD4+ and CD8+ T cells are resistant to activation-induced cell death having about half the apoptosis rates as controls
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• spleens are increased in weight by about 50% at 4 months of age
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• there is about a 50% increase in the number of cells found in the spleen at 4 months of age
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• the white pulp of the spleen is greatly increased to the point of destroying the spleen micro-architecture
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• splenic B cells produce significantly more IL-1beta and TNF upon stimulation with LPS or CpG
• responses to anti-IgM stimulation including TNF production, proliferation, and class switching are all normal in these mice
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• the number of B cells expressing CD69+ is greatly increased in the spleen of 4 month old mice
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• levels are reduced in the sera of 4 month old mice
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• levels are reduced in the sera of 4 month old mice
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• CD4+ T cells responses are hyperactive to in vitro TCR stimulation
• in vitro activation of these cells leads to enhanced secretion of IL-2, IL-4, IL-6, IL-17, and IFN-gamma
• there is higher expression of the activation markers CD25, CD44, and CD69 after TCR ligation compared to controls
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• CD8 T cell responses to lymphocytic choriomeningitis virus (LCMV) are augmented in these mice
• mice have 5-fold more CD8+ T cells that are reactive to LCMV eight days after infection compared to wild-type mice
• splenocytes from infected mice also make twice as much IFN-gamma as controls when cultured with LCMV-derived peptides that are antigenic to CD8 + T cells
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• bone marrow derived macrophages activated in vitro with LPS produce significantly more IL-6 and IL-12 than controls
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• IL-1beta levels are vastly increased in the sera of 4-month old mice
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• IL-10 levels are vastly increased in the sera of 4-month old mice
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• IL-12 levels are vastly increased in the sera of 4-month old mice
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• IL-6 levels are increased about 3-fold in the sera of 4-month old mice
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• TNF levels are vastly increased in the sera of 4-month old mice
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• in vitro activation of CD4+ T cells leads to enhanced secretion of IFN-gamma
• splenocytes from LCMV-infected mice produce more IFN-gamma upon stimulation with antigenic peptide derived from LCMV
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• IL-1beta levels are vastly increased in the sera of 4-month old mice
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• bone marrow derived macrophages activated in vitro with LPS produce significantly more IL-12 than controls
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• in vitro activation of CD4+ T cells leads to enhanced secretion of IL-17
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• in vitro activation of CD4+ T cells leads to enhanced secretion of IL-2
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• in vitro activation of CD4+ T cells leads to enhanced secretion of IL-4
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• in vitro activation of CD4+ T cells leads to enhanced secretion of IL-6
• bone marrow derived macrophages activated in vitro with LPS produce significantly more IL-6 than controls
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• splenic B cells produce significantly more TNF upon stimulation with LPS or CpG
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• is observed in mice as part of systemic autoimmune disease starting at 3 months of age
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• is observed in mice as part of systemic autoimmune disease starting at 3 months of age
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• all mice die within 4 days of I.V. administration of a low dose of LPS while only 2 of 11 controls die within the same time period
• sera levels of IL-1, IL-6, and IL-12 in mice treated with LPS are greatly augmented
• severe multi-organ necrosis occurs in these mice when treated with low dose LPS
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• starting at two months of age, mice develop a chronic systemic autoimmune disease that eventually proves fatal
• mononuclear cell infiltration occurs in multiple organs is noted by 3 months of age including in the lung, liver, and intestine
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• is observed in mice as part of systemic autoimmune disease starting at 3 months of age
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• interstitial lung inflammation is observed in mice starting at 3 months of age as part of a systemic autoimmune disease
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digestive/alimentary system
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• is observed in mice as part of systemic autoimmune disease starting at 3 months of age
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liver/biliary system
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• is observed in mice as part of systemic autoimmune disease starting at 3 months of age
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respiratory system
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• interstitial lung inflammation is observed in mice starting at 3 months of age as part of a systemic autoimmune disease
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homeostasis/metabolism
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• IL-1beta levels are vastly increased in the sera of 4-month old mice
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• IL-10 levels are vastly increased in the sera of 4-month old mice
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• IL-12 levels are vastly increased in the sera of 4-month old mice
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• IL-6 levels are increased about 3-fold in the sera of 4-month old mice
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• TNF levels are vastly increased in the sera of 4-month old mice
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hematopoietic system
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• B cell numbers in the spleen of 4-month old mice are increased by about half
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• T cell numbers in the spleen of 4-month old mice are increased by about half
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• CD11b+ cells in the spleen of 4-month old mice are increased by more than half
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• both CD4+ and CD8+ T cells are resistant to activation-induced cell death having about half the apoptosis rates as controls
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• spleens are increased in weight by about 50% at 4 months of age
|
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• there is about a 50% increase in the number of cells found in the spleen at 4 months of age
|
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• the white pulp of the spleen is greatly increased to the point of destroying the spleen micro-architecture
|
|
• splenic B cells produce significantly more IL-1beta and TNF upon stimulation with LPS or CpG
• responses to anti-IgM stimulation including TNF production, proliferation, and class switching are all normal in these mice
|
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• the number of B cells expressing CD69+ is greatly increased in the spleen of 4 month old mice
|
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• levels are reduced in the sera of 4 month old mice
|
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• levels are reduced in the sera of 4 month old mice
|
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• CD4+ T cells responses are hyperactive to in vitro TCR stimulation
• in vitro activation of these cells leads to enhanced secretion of IL-2, IL-4, IL-6, IL-17, and IFN-gamma
• there is higher expression of the activation markers CD25, CD44, and CD69 after TCR ligation compared to controls
|
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• CD8 T cell responses to lymphocytic choriomeningitis virus (LCMV) are augmented in these mice
• mice have 5-fold more CD8+ T cells that are reactive to LCMV eight days after infection compared to wild-type mice
• splenocytes from infected mice also make twice as much IFN-gamma as controls when cultured with LCMV-derived peptides that are antigenic to CD8 + T cells
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• bone marrow derived macrophages activated in vitro with LPS produce significantly more IL-6 and IL-12 than controls
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cellular
