Analysis Tools
mortality/aging
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• though present in Mendelian ratios at E18.5, mice no viable mice are born
• mice delivered by Caesarian die within an hour of birth
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renal/urinary system
| N |
• despite defects in the ureters, mice exhibit a normal bladder
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• explants of E15.5 ureters completely fail to exhibit peristaltic contraction unlike wild-type explants
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• mice exhibit dilation of the renal pelvis
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• from E16.5, mice exhibit bilateral hydronephrosis
• however, no physical obstructions are detected
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• the structural organization of muscular layers is lost leading to thin layers of mesenchymal cells unlike in wild-type mice
• however, the distal ureters are normal and mesenchymal progenitors condense normally until E15.5
• at E16, peri-urothelial cells of ureters are less organized than in wild-type mice
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• development of proximal ureteric smooth muscle cells is impaired as determined by expression of smooth muscle markers
• however, proliferation and apoptosis of periureteric cells, differentiation of uroepithelium, and development of stromal cells are normal
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• development of proximal ureteric smooth muscles is impaired as determined by expression of smooth muscle markers
• however, smooth muscle development in the bladder and proliferation and apoptosis of ureteric smooth muscle precursors are normal
• the structural organization of muscular layers is lost leading to thin layers of mesenchymal cells unlike in wild-type mice
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• mice exhibit dilated proximal ureters with thin walls
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hydroureter
(
J:138769
)
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• from E16.5, mice exhibit prominent bilateral proximal hydroureter
• however, no physical obstructions are detected
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respiratory system
atelectasis
(
J:138769
)
|
• lungs fail to inflate as indicated by their sinking instead of floating on water as do wild-type lungs
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• at birth, mice do not breath
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behavior/neurological
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• at birth, mice only respond to strong stimuli
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• at birth
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muscle
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• explants of E15.5 ureters completely fail to exhibit peristaltic contraction unlike wild-type explants
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