Analysis Tools
mortality/aging
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• mice were euthanized at 13 days of age due to no weight gain and seizures
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nervous system
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• 12 day old pups suffer seizures when touched by littermates
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• E15.5 cortical neurons cultured in vitro die within 7 days of withdrawal of the anti-oxidant alpha-tocopherol
• this cell death occurs by a poorly defined death pathway involving the protein Aifm1
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• damaged and pyknotic cells in the pyramidal layer of the CA3 region are found in mice 13 days of age
• parvalbumin-positive cells were largely lost from CA3 region due to apoptosis
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• astrogliosis, apoptosis, and loss of parvalbumin-expressing cells occur in the somatosensory cortex of 13 day old mice
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astrocytosis
(
J:139668
)
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• astrogliosis occurs in the somatosensory cortex and the CA3 region of the hippocampus of 13-day old mice
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growth/size/body
weight loss
(
J:139668
)
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• mice cease weight gain starting at 8 days of age until being euthanized at 13 days of age
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behavior/neurological
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• mice consistently bury themselves vertically in cage bedding
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• 12 day old pups suffer seizures when touched by littermates
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cellular
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• E15.5 cortical neurons cultured in vitro die within 7 days of withdrawal of the anti-oxidant alpha-tocopherol
• this cell death occurs by a poorly defined death pathway involving the protein Aifm1
|
