All Phenotypes Itm2b<tm1.1Ldad> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Itm2b^tm1.1Ldad
targeted mutation 1.1, Luciano D'Adamio
MGI:3810987

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Itm2b^tm1.1Ldad/Itm2b^tm1.1Ldad	involves: 129	MGI:4867887
hm2	Itm2b^tm1.1Ldad/Itm2b^tm1.1Ldad	involves: 129 * C57BL/6J	MGI:3810991
ht3	Itm2b^tm1.1Ldad/Itm2b⁺	B6.129-Itm2b^tm1.1Ldad	MGI:4936846
cx4	Itm2b^tm1.1Ldad/Itm2b⁺ Tg(APPswe,PSEN1dE9)85Dbo/0	involves: 129 * C3H * C57BL/6	MGI:3810993

Allelic Composition	Itm2b^tm1.1Ldad/Itm2b^tm1.1Ldad
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itm2b^tm1.1Ldad mutation (0 available); any Itm2b mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

impaired contextual conditioning behavior ( J:166696 )

impaired long-term object recognition memory ( J:166696 )

• mice spend the same time exploring a novel and familiar object introduced 24 hours prior unlike wild-type mice

abnormal spatial working memory ( J:166696 )

• mice exhibit impaired spatial working memory compared with wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cerebral amyloid angiopathy		DOID:9246		J:166696

Allelic Composition	Itm2b^tm1.1Ldad/Itm2b^tm1.1Ldad
Genetic Background	involves: 129 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itm2b^tm1.1Ldad mutation (0 available); any Itm2b mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal nervous system physiology ( J:138796 )

• at 11 months of age levels of soluble APP-alpha and APP-beta are increased in the brain

• however, no obvious change in overall APP levels is detected

Allelic Composition	Itm2b^tm1.1Ldad/Itm2b⁺
Genetic Background	B6.129-Itm2b^tm1.1Ldad

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itm2b^tm1.1Ldad mutation (0 available); any Itm2b mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

impaired contextual conditioning behavior ( J:167154 )

abnormal object recognition memory ( J:167154 )

• mice spend equal time exploring novel and old objects unlike wild-type mice

impaired spatial working memory ( J:167154 )

• mice exhibit impaired spatial working memory in a radial-arm water maze compared with wild-type mice

nervous system

reduced long-term potentiation ( J:167154 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cerebral amyloid angiopathy		DOID:9246		J:167154

Allelic Composition	Itm2b^tm1.1Ldad/Itm2b⁺ Tg(APPswe,PSEN1dE9)85Dbo/0
Genetic Background	involves: 129 * C3H * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itm2b^tm1.1Ldad mutation (0 available); any Itm2b mutation (18 available)
Tg(APPswe,PSEN1dE9)85Dbo mutation (6 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal nervous system physiology ( J:138796 )

• obvious increase in soluble APP-alpha in brain homogenates

• significant increase in both Abeta40 and Abeta42 compared to mice wild-type for Itm2b

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24