Phenotypes associated with this allele

• Allele Symbol: Tg(Camk2a-ITM2B)8.4Ldad
• Allele Name: transgene insertion 8.4, Luciano D'Adamio
• Allele ID: MGI:3810989
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Itm2b^tm2.1Ldad/Itm2b^+ Tg(Camk2a-ITM2B)8.4Ldad/0	B6.Cg-Itm2b^tm2.1Ldad Tg(Camk2a-ITM2B)8.4Ldad	MGI:4936848
cx2	Tg(Camk2a-ITM2B)8.4Ldad/0 Tg(PRNP-APPSweInd)8Dwst/0	involves: C3H/HeJ * C57BL/6J * FVB/N	MGI:3810992

Genotype
MGI:4936848

cx1

• Allelic Composition: Itm2b^tm2.1Ldad/Itm2b⁺; Tg(Camk2a-ITM2B)8.4Ldad/0
• Genetic Background: B6.Cg-Itm2b^tm2.1Ldad Tg(Camk2a-ITM2B)8.4Ldad

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:167154 )

N • mice exhibit normal spatial working memory and novel object recognition

Genotype
MGI:3810992

cx2

• Allelic Composition: Tg(Camk2a-ITM2B)8.4Ldad/0; Tg(PRNP-APPSweInd)8Dwst/0
• Genetic Background: involves: C3H/HeJ * C57BL/6J * FVB/N

nervous system

amyloid beta deposits ( J:138796 )

• reduction in plaque formation compared to mice carrying just Tg(PRNP-APPSweInd)8Dwst

homeostasis/metabolism

amyloid beta deposits ( J:138796 )

• reduction in plaque formation compared to mice carrying just Tg(PRNP-APPSweInd)8Dwst