homeostasis/metabolism
• VEGF mediated increase in calcium ion mobilization in the cytoplasm of endothelial cells is inhibited
• ATP mediated calcium ion mobilization is normal
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cardiovascular system
• no significant increase in the number of blood vessels in the area of injury after hind limb ischemia whereas controls display a noticeable increase
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• reduced endothelial precursor cell mobilization
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• acetylcholine induced relaxation of norepinephrine constricted aorta is weakened
• blood flow recovery after hind limb ischemia is much lower after 3 weeks
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muscle
• acetylcholine induced relaxation of norepinephrine constricted aorta is weakened
• blood flow recovery after hind limb ischemia is much lower after 3 weeks
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cellular
• reduced endothelial precursor cell mobilization
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