Phenotypes associated with this allele

• Allele Symbol: Tg(CAG-lacZ,-Akt1*,-EGFP)56Ebm
• Allele Name: transgene insertion 56, Ernesto Bernal-Mizrachi
• Allele ID: MGI:3811006
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Tg(CAG-lacZ,-Akt1*,-EGFP)56Ebm/0 Tg(Fabp7-cre,-lacZ)3Gtm/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	MGI:3811010

Genotype
MGI:3811010

cn1

• Allelic Composition: Tg(CAG-lacZ,-Akt1*,-EGFP)56Ebm/0; Tg(Fabp7-cre,-lacZ)3Gtm/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:139866 )

N • unlike mice homozygous for Nf1^tm1Par and hemizygous for Tg(Fabp7-cre)2Gtm , mice are viable with no reduction in life span

nervous system

nervous system phenotype ( J:139866 )

N • unlike mice homozygous for Nf1^tm1Par and hemizygous for Tg(Fabp7-cre)2Gtm no change in pyramidal neuron apical dendrite length or neuritic development are detected

abnormal brain development ( J:139866 )

• increase in the number of Olig2+ progenitor cells

abnormal hippocampus morphology ( J:139866 )

• an increase in proliferating cells is seen in the CA2/3 region

abnormal CNS glial cell morphology ( J:139866 )

• expansion of glial cells similar to that in mice homozygous for Nf1^tm1Par and hemizygous for Tg(Fabp7-cre)2Gtm

abnormal astrocyte morphology ( J:139866 )

• increase in the number of GFAP+ astrocytes in the brain

growth/size/body

growth/size/body region phenotype ( J:139866 )

N • unlike mice homozygous for Nf1^tm1Par and hemizygous for Tg(Fabp7-cre)2Gtm , no growth retardation is seen

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:139866 )

N • unlike mice homozygous for Nf1^tm1Par and hemizygous for Tg(Fabp7-cre)2Gtm , no impairment in pituitary gland development is detected