Analysis Tools
behavior/neurological
| N |
• mice exhibit normal neuromuscular strength, sensitivity to painful stimulus, sensorimotor reflexes, spatial learning memory, and anxiety related behaviors
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• mice exhibit enhanced food reward and reinforcement compared to in wild-type mice
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• mice exhibit decreased frequency of freezing during contextual conditioning compared to wild-type mice
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• mice exhibit decreased frequency of freezing during cued conditioning compared to wild-type mice
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• in an open field test
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• in an open field test, mice exhibit increased distance traveled, vertical activity and stereotypic activity compared to wild-type mice
• mice exhibit increased distance traveled compared to wild-type mice in an elevated plus-maze, light-dark transition and social interaction in a novel environment test
• mice exhibit decreased immobility time in a forced swim test compared to in wild-type mice
• when treated with 0.25 mg/kg MK-801 (an NMDA glutamate receptor inhibitor), mice exhibit a greater increase in locomotion compared to in similarly treated wild-type mice
• however, response to 0.1 mg/kg of MLK-801 is normal
• mice exhibit a greater increase in locomotion following daily treatment with methamphetamine compared to similarly treated wild-type mice
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• in an open field test
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nervous system
| N |
• mice exhibit normal prepulse inhibition
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growth/size/body
homeostasis/metabolism
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• following treatment with methamphetamine, dopamine levels are increased more than in similarly treated wild-type mice
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