Analysis Tools
mortality/aging
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• 7 of 27 mice were born dead with very abnormal lungs
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respiratory system
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• in all mice
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• mice exhibit lung hypercellularity due to a 4-fold increased in proliferation in the lungs
• the lungs of mice that die at birth exhibit a 3-fold increase in the number of neuroendocrine cell clusters in their lungs compared to in wild-type mice
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• at P0, epithelial progenitor cells persist in the lungs unlike in wild-type mice
• differentiation of proximal cells is delayed compared to in wild-type mice
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• at E18.5, the number of alveoli is decreased compared to in wild-type mice and are packed with numerous epithelial cells
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atelectasis
(
J:128019
)
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• no air is found within the lungs of mice that die at birth
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growth/size/body
|
• mice exhibit lung hypercellularity due to a 4-fold increased in proliferation in the lungs
• the lungs of mice that die at birth exhibit a 3-fold increase in the number of neuroendocrine cell clusters in their lungs compared to in wild-type mice
|
