Phenotypes associated with this allele

• Allele Symbol: Tg(THY1-SNCA*A53T)F53Sud
• Allele Name: transgene insertion F53, Thomas C Sudhof
• Allele ID: MGI:3811331
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(THY1-SNCA*A53T)F53Sud/0	involves: C57BL/6	MGI:3811387

Genotype
MGI:3811387

tg1

• Allelic Composition: Tg(THY1-SNCA*A53T)F53Sud/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

tremors ( J:140019 )

• resting tremor initially observed around 8 months of age

hindlimb paralysis ( J:140019 )

• initially observed around 8 months of age

nervous system

increased neuron apoptosis ( J:140019 )

• cell death is seen in spinal cord and is extensive in brain

motor neuron degeneration ( J:140019 )

• results in hindlimb paralysis around 8 months of age

cellular

increased neuron apoptosis ( J:140019 )

• cell death is seen in spinal cord and is extensive in brain