Phenotypes associated with this allele

• Allele Symbol: Tlr7^rsq2
• Allele Name: resiquimod unresponsive 2
• Allele ID: MGI:3811335
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ot1	Tlr7^rsq2/Y	C57BL/6J-Tlr7^rsq2	MGI:3811355

Genotype
MGI:3811355

ot1

• Allelic Composition: Tlr7^rsq2/Y
• Genetic Background: C57BL/6J-Tlr7^rsq2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal macrophage physiology ( J:140020 )

♂ • peritoneal macrophages from hemizygous mutant male mice fail to produce tumor necrosis factor (TNF) alpha in response to R-848, a single stranded RNA analog that signals via TLR7

♂ • TNF-alpha production by hemizygous mutant macrophages is normal following stimulation with macrophage activating lipopeptide 2 (MALP-2, TLR2/6 ligand), CpG oligodeoxynucleotides (CpG ODN, TLR9 ligand), Pam3CSK4 (a triacyl lipopeptide, TLR1/2 ligand), poly I:C (TLR3 ligand) or lipopolysaccharide (LPS, TLR4 ligand)

decreased tumor necrosis factor secretion ( J:140020 )

♂ • peritoneal macrophages from hemizygous mutant male mice fail to produce tumor necrosis factor (TNF) alpha in response to R-848, a single stranded RNA analog that signals via TLR7

♂ • TNF-alpha production by hemizygous mutant macrophages is normal following stimulation with macrophage activating lipopeptide 2 (MALP-2, TLR2/6 ligand), CpG oligodeoxynucleotides (CpG ODN, TLR9 ligand), Pam3CSK4 (a triacyl lipopeptide, TLR1/2 ligand), poly I:C (TLR3 ligand) or lipopolysaccharide (LPS, TLR4 ligand)

hematopoietic system

abnormal macrophage physiology ( J:140020 )

♂ • peritoneal macrophages from hemizygous mutant male mice fail to produce tumor necrosis factor (TNF) alpha in response to R-848, a single stranded RNA analog that signals via TLR7

♂ • TNF-alpha production by hemizygous mutant macrophages is normal following stimulation with macrophage activating lipopeptide 2 (MALP-2, TLR2/6 ligand), CpG oligodeoxynucleotides (CpG ODN, TLR9 ligand), Pam3CSK4 (a triacyl lipopeptide, TLR1/2 ligand), poly I:C (TLR3 ligand) or lipopolysaccharide (LPS, TLR4 ligand)