Phenotypes associated with this allele

• Allele Symbol: Slc5a8^tm1.1Boet
• Allele Name: targeted mutation 1.1, Thomas Boettger
• Allele ID: MGI:3811502
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc5a8^tm1.1Boet/Slc5a8^tm1.1Boet	involves: C57BL/6	MGI:3811519
cx2	Slc26a4^tm1Egr/Slc26a4^tm1Egr Slc5a8^tm1.1Boet/Slc5a8^tm1.1Boet	involves: 129S6/SvEvTac * C57BL/6	MGI:3811521
cx3	Apc^Min/Apc^+ Slc5a8^tm1.1Boet/Slc5a8^tm1.1Boet	involves: C57BL/6 * C57BL/6J	MGI:3811523

Genotype
MGI:3811519

hm1

• Allelic Composition: Slc5a8^tm1.1Boet/Slc5a8^tm1.1Boet
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal urine homeostasis ( J:139883 )

• mice exhibit a 67-fold increase in urinary lactate concentration compared to in wild-type mice

• however, urinary concentrations of sodium, potassium, magnesium, calcium and chloride ions, inorganic phosphate, creatinine, glucose, urea and uric acid as well as blood lactate levels are normal

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:139883 )

N • thyroid morphology and function are normal

abnormal salivary gland physiology ( J:139883 )

• saliva concentrations of lactate are greater than in wild-type mice

neoplasm

neoplasm ( J:139883 )

N • mice do not exhibit any increase in incidence of spontaneous or UV induced tumors

renal/urinary system

renal/urinary system phenotype ( J:139883 )

N • despite increased urinary lactate, kidney morphology is normal

abnormal urine homeostasis ( J:139883 )

• mice exhibit a 67-fold increase in urinary lactate concentration compared to in wild-type mice

• however, urinary concentrations of sodium, potassium, magnesium, calcium and chloride ions, inorganic phosphate, creatinine, glucose, urea and uric acid as well as blood lactate levels are normal

digestive/alimentary system

abnormal salivary gland physiology ( J:139883 )

• saliva concentrations of lactate are greater than in wild-type mice

Genotype
MGI:3811521

cx2

• Allelic Composition: Slc26a4^tm1Egr/Slc26a4^tm1Egr; Slc5a8^tm1.1Boet/Slc5a8^tm1.1Boet
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:139883 )

N • thyroid morphology and function are normal

Genotype
MGI:3811523

cx3

• Allelic Composition: Apc^Min/Apc⁺; Slc5a8^tm1.1Boet/Slc5a8^tm1.1Boet
• Genetic Background: involves: C57BL/6 * C57BL/6J

neoplasm

increased colon adenoma incidence ( J:139883 )

• mice develop colon tumors at the same rate as Apc^Min homozygotes

digestive/alimentary system

increased colon adenoma incidence ( J:139883 )

• mice develop colon tumors at the same rate as Apc^Min homozygotes