Analysis Tools
vision/eye
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• mice are pre-disposed to developing nuclear cataracts as they age but otherwise have a normal eye phenotype
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Allele Symbol Allele Name Allele ID |
Tg(Cryaa-cre,Tyr)39Mlr transgene insertion 39, Mike Robinson MGI:3811526 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice are pre-disposed to developing nuclear cataracts as they age but otherwise have a normal eye phenotype
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in the anterior, posterior, and center of the lens
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• lenses exhibit an abnormal shape with shortened anterior-posterior dimension
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• denucleation of the fiber cell compartment is delayed compared to in wild-type mice
• anterior and posterior suture formation is defective
• differentiation of fiber cells is disrupted
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• in some mice fiber cells fail to exhibit convex curvature and in other cases have an irregular curvature unlike in wild-type mice
• differentiation of fiber cells is disrupted
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• at P2
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• in the anterior, posterior, and center of the lens
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 06/12/2024 MGI 6.13 |
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