Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tbx4tm1.2Pa targeted mutation 1.2, Virginia Papaioannou MGI:3811603 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at E15.5, mice exhibit mild or nonexistent anterior digit fusions
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• the second digit of the foot is reduced compared to in wild-type mice
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• mice exhibit a partial fusion of the tarsals
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• hindlimbs are turned nearly backwards and do not articulate with the pelvis unlike in wild-type mice
• however, despite reduced hindlimb features apoptosis rates in the hindlimb are normal
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• at E15.5, mice exhibit severely hypoplastic femurs that fail to ossify
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• at E15.5, mice exhibit hypoplastic fibulas that fail to ossify
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• at E15.5, mice exhibit mild or nonexistent anterior digit fusions
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• mice exhibit a partial fusion of the tarsals
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• at E15.5, mice exhibit severely hypoplastic femurs that fail to ossify
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• at E15.5, mice exhibit hypoplastic fibulas that fail to ossify
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• at E15.5, mice exhibit hypoplastic pelvis
• the ischium is fused to the illeum
• neonates exhibit small hips
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• the pelvic rami are absent and the ischium is fused to the illeum
• however, apoptosis rates in the hindlimb are normal
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• following tamoxifen treatment at E6.5, all mice die at E10.5 due to failure of chorioallantoic fusion
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• following tamoxifen treatment at E7.5, 50% of mice die at E10.5 due to failure of chorioallantoic fusion
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| N |
• despite defects in hindlimb formation following treatment with tamoxifen at E9.5 and E10.5, mice exhibit normal hindlimb identity and forelimb development
• mice treated with tamoxifen at E11.5 exhibit normal hindlimb morphology
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• following tamoxifen treatment at E7.5, limb buds form but are degenerating by E11.5 with hindlimb limited outgrowth
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• following tamoxifen treatment at E9.5, the autopod of the hindlimb is thin
• following tamoxifen treatment at E9.5, the space between expression domains of Tbx2 and Tbx3 expression are narrower than in wild type mice and the hindlimb autopod contains fewer cells than in wild-type mice
• however, there is no reduction in cell proliferation rates in the hindlimb autopods of tamoxifen treated mice
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• following tamoxifen treatment at E9.5 or E10.5, mice exhibit abnormal anterior digits of the hindlimb
• following tamoxifen treatment at E10.5, some mice exhibit thin hindlimb digits I and II
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• following tamoxifen treatment at E9.5, 33% of mice exhibit fusion of the anterior hindlimb digit; some with parital fusions of digits I and II and others with 4 digits indicating the loss of digit II or fusion of digits I and II
• following tamoxifen treatment at E10.5, 42% of mice exhibit fusion of the anterior hindlimb digits
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• following tamoxifen treatment at E9.5, 67% of mice exhibit four symmetrical hindlimb digits
• following tamoxifen treatment at E9.5, digits I and II are partially fused in some mice while others have 4 digits indicating the loss of digit II or fusion of digits I and II
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• following tamoxifen treatment at E9.5 or E10.5, mice exhibit aplastic or severely hypoplastic femurs that do not articulate with the pelvis
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• following tamoxifen treatment at E9.5 or E10.5, mice exhibit aplastic or severely hypoplastic femurs that do not articulate with the pelvis
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• following tamoxifen treatment at E9.5 or E10.5, mice exhibit hypoplastic fibulas
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• following tamoxifen treatment at E9.5 and E10.5, the hindlimb is shorter than in wild type mice at E14.5
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• following tamoxifen treatment at E10.5, some mice exhibit a metatarsal of the first digit that originates near the middle of the metatarsal of digit two instead of near the tarsal bone
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• following tamoxifen treatment at E7.5, limb buds form but are degenerating by E11.5 with hindlimb limited outgrowth
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• following tamoxifen treatment at E6.5, mice die at E10.5 due to failure of chorioallantoic fusion
• following tamoxifen treatment at E7.5, 50% of mice die at E10.5 due to failure of chorioallantoic fusion
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• following tamoxifen treatment at E9.5, 33% of mice exhibit fusion of the anterior hindlimb digit; some with parital fusions of digits I and II and others with 4 digits indicating the loss of digit II or fusion of digits I and II
• following tamoxifen treatment at E10.5, 42% of mice exhibit fusion of the anterior hindlimb digits
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• following tamoxifen treatment at E9.5 or E10.5, mice exhibit aplastic or severely hypoplastic femurs that do not articulate with the pelvis
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• following tamoxifen treatment at E9.5 or E10.5, mice exhibit aplastic or severely hypoplastic femurs that do not articulate with the pelvis
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• following tamoxifen treatment at E9.5 or E10.5, mice exhibit hypoplastic fibulas
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• following tamoxifen treatment at E10.5, some mice exhibit a metatarsal of the first digit that originates near the middle of the metatarsal of digit two instead of near the tarsal bone
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• following tamoxifen treatment at E9.5 or E10.5, mice exhibit abnormal pelvic connections and hypoplastic pelvises
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at E16.5 in contrast to wild-type hindlimbs, in the analogous regions to the musculus lumbricales (Lum) and m flexor digitorum brevis (fdb) in mutant limbs, muscles misinsert and display the wrong shape with tamoxifen treatment at E10.5
• all limb musculature is affected
• limb muscle formation is unaffected if tamoxifen administration is done at E12.5
• terminal differentiation of limb muscle is not affected
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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