Analysis Tools
behavior/neurological
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• vertical activities in a new environment are reduced by two-thirds
• similar results are obtained in an elevated maze test
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• increased levels of anxiety-related behaviors are detected across different test paradigms with males having more pronounced behaviors
• males have about a two-thirds reduction and females have a third to a half reduction in time spent in the center of an open field
• male mice but not female mice show a reduced amount of time in the open arm of an elevated maze test
• mutant males spend less time in the aversive illuminated compartment of a light-dark test with the ratio of distance traveled in lit areas (to total distance traveled) being half that of sex-matched controls
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• vertical activities of mutant mice are reduced by two-third in open field tests
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• mice of both sexes have reduced motor activity in an open field tests(371.1 movements vs. 585.5 movements for males)
• both mutant and wild-type female mice have higher locomotion than male mice of the same genotype (479.8 movements vs. 630.7 movements for wild-type females)
• similar results occur in light-dark field tests
• mutant mice also have longer resting duration time in an open field test (393.3 seconds vs. 347.2 s in wild-type females)
• male mice have increased resting times compared to female mice (462.7s vs. 381.6s)
• similar resting results occur in light-dark field tests
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digestive/alimentary system
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• female mice have increased rates of defecation in elevated maze tests (2.8 vs. 0.1 in controls)
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